Sara B Keller
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Explore the profile of Sara B Keller including associated specialties, affiliations and a list of published articles.
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11
Citations
47
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Recent Articles
1.
Sonosensitive Cavitation Nuclei-A Customisable Platform Technology for Enhanced Therapeutic Delivery
Lyons B, Balkaran J, Dunn-Lawless D, Lucian V, Keller S, OReilly C, et al.
Molecules
. 2023 Dec;
28(23).
PMID: 38067464
Ultrasound-mediated cavitation shows great promise for improving targeted drug delivery across a range of clinical applications. Cavitation nuclei-sound-sensitive constructs that enhance cavitation activity at lower pressures-have become a powerful adjuvant...
2.
Pattinson O, Keller S, Evans N, Pierron F, Carugo D
ACS Biomater Sci Eng
. 2023 Sep;
9(10):5912-5923.
PMID: 37747762
Microbubbles utilize high-frequency oscillations under ultrasound stimulation to induce a range of therapeutic effects in cells, often through mechanical stimulation and permeabilization of cells. One of the largest challenges remaining...
3.
Lutheryn G, Hind C, Campbell C, Crowther A, Wu Q, Keller S, et al.
Front Cell Infect Microbiol
. 2022 Aug;
12:956808.
PMID: 35992170
Bacterial biofilms are a major and ongoing concern for public health, featuring both inherited genetic resistance traits and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a...
4.
Keller S, Lai T, De Koninck L, Averkiou M
IEEE Trans Ultrason Ferroelectr Freq Control
. 2022 Jan;
69(3):1032-1040.
PMID: 35073259
Contrast-enhanced ultrasound (CEUS) imaging relies on distinguishing between microbubble and tissue echoes. Amplitude modulation (AM), a nonlinear pulsing scheme, has been developed to take advantage of the amplitude-dependent nonlinearity of...
5.
Keller S, Averkiou M
Bioconjug Chem
. 2021 Sep;
33(6):1049-1056.
PMID: 34514776
The unique microenvironment of solid tumors, including desmoplasia within the extracellular matrix, enhanced vascular permeability, and poor lymphatic drainage, leads to an elevated interstitial fluid pressure which is a major...
6.
Keller S, Wang Y, Totten S, Yeung R, Averkiou M
Ultrasound Med Biol
. 2021 Aug;
47(11):3211-3220.
PMID: 34362584
Ultrasound and microbubbles are useful for both diagnostic imaging and targeted drug delivery, making them ideal conduits for theranostic interventions. Recent reports have indicated the preclinical success of microbubble cavitation...
7.
Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity
Keller S, Bumpus J, Gatenby J, Yang E, Kassim A, Dampier C, et al.
Cardiovasc Eng Technol
. 2021 Jul;
13(1):104-119.
PMID: 34286479
Purpose: Pediatric and adult patients with sickle cell anemia (SCA) are at increased risk of stroke and cerebrovascular accident. In the general adult population, there is a relationship between arterial...
8.
Keller S, Sheeran P, Averkiou M
IEEE Trans Ultrason Ferroelectr Freq Control
. 2020 Oct;
68(4):1144-1154.
PMID: 33112743
The ability to monitor cavitation activity during ultrasound and microbubble-mediated procedures is of high clinical value. However, there has been little reported literature comparing the cavitation characteristics of different clinical...
9.
Keller S, Suo D, Wang Y, Kenerson H, Yeung R, Averkiou M
Front Pharmacol
. 2020 Oct;
11:584344.
PMID: 33101038
Despite advances in interventional procedures and chemotherapeutic drug development, hepatocellular carcinoma (HCC) is still the fourth leading cause of cancer-related deaths worldwide with a <30% 5-year survival rate. This poor...
10.
Juang E, De Cock I, Keravnou C, Gallagher M, Keller S, Zheng Y, et al.
Langmuir
. 2018 Dec;
35(31):10128-10138.
PMID: 30540481
Localized and targeted drug delivery can be achieved by the combined action of ultrasound and microbubbles on the tumor microenvironment, likely through sonoporation and other therapeutic mechanisms that are not...