Santosh Narayan
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Explore the profile of Santosh Narayan including associated specialties, affiliations and a list of published articles.
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10
Citations
269
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Recent Articles
1.
Narayan S, Bryant G, Shah S, Berrozpe G, Ptashne M
Cell Rep
. 2017 Aug;
20(7):1585-1596.
PMID: 28813671
SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional...
2.
Berrozpe G, Bryant G, Warpinski K, Spagna D, Narayan S, Shah S, et al.
Cell Rep
. 2017 Jul;
20(4):785-793.
PMID: 28746865
How is Polycomb (Pc), a eukaryotic negative regulator of transcription, targeted to specific mammalian genes? Our genome-wide analysis of the Pc mark H3K27me3 in murine cells revealed that Pc is...
3.
Hammachi F, Morrison G, Sharov A, Livigni A, Narayan S, Papapetrou E, et al.
Cell Rep
. 2012 Jul;
1(2):99-109.
PMID: 22832160
Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced...
4.
Narayan S, Prasanna G, Tchedre K, Krishnamoorthy R, Yorio T
J Ocul Pharmacol Ther
. 2010 Sep;
26(5):389-97.
PMID: 20874501
Purpose: The retinal pigment epithelium (RPE) is a major source for endothelin-1 (ET-1), a potent vasoactive peptide, at the outer blood–retinal barrier. Factors that regulate ET-1 synthesis at this site...
5.
Floer M, Wang X, Prabhu V, Berrozpe G, Narayan S, Spagna D, et al.
Cell
. 2010 May;
141(3):407-18.
PMID: 20434983
How is chromatin architecture established and what role does it play in transcription? We show that the yeast regulatory locus UASg bears, in addition to binding sites for the activator...
6.
Prasanna G, Hulet C, Desai D, Krishnamoorthy R, Narayan S, Brun A, et al.
Pharmacol Res
. 2004 Nov;
51(1):41-50.
PMID: 15519534
The role of endothelin-1 (ET-1) a potent vasoactive peptide, in glaucoma pathogenesis is receiving increasing attention, particularly in astroglial activation in optic nerve damage. Our laboratory has also shown that...
7.
Narayan S, Brun A, Yorio T
Exp Eye Res
. 2004 Jun;
79(1):11-9.
PMID: 15183096
Endothelins are a family of conserved vasoactive peptides that are widely expressed in different biological systems including the eye. In the cell culture model of retinal pigment epithelium, ARPE-19, the...
8.
Prasanna G, Narayan S, Krishnamoorthy R, Yorio T
Mol Cell Biochem
. 2003 Nov;
253(1-2):71-88.
PMID: 14619958
Endothelin is an endogenous vasoactive peptide that is considered among the most potent vasoconstrictor substances known. In addition to its vascular effects, endothelins and their receptors have been shown to...
9.
Narayan S, Prasanna G, Krishnamoorthy R, Zhang X, Yorio T
Invest Ophthalmol Vis Sci
. 2003 Oct;
44(11):4885-94.
PMID: 14578413
Purpose: Endothelin (ET)-1 can produce nerve damage analogous to that in optic neuropathies such as glaucoma. The precise source of endothelin in the posterior segment of the eye remains unclear....
10.
Zhang X, Krishnamoorthy R, Prasanna G, Narayan S, Clark A, Yorio T
Exp Eye Res
. 2003 Feb;
76(3):261-72.
PMID: 12573655
Endothelin-1 (ET-1) lowers intraocular pressure (IOP) in animal models by regulating aqueous humour dynamics through both inflow and outflow mechanisms. Moreover, ET's concentration is elevated in glaucoma patients and in...