Santiago Rodriguez Ospina
Overview
Explore the profile of Santiago Rodriguez Ospina including associated specialties, affiliations and a list of published articles.
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9
Citations
70
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0
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Recent Articles
1.
Hill S, Beaulieu-Abdelahad D, Lemus A, Webster J, Ospina S, Darling A, et al.
ACS Chem Biol
. 2023 May;
18(5):1124-1135.
PMID: 37144894
The accumulation and aggregation of the microtubule-associated protein tau (tau) into intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative tauopathies, including Alzheimer's disease (AD), frontotemporal dementia,...
2.
Viennet T, Ospina S, Lu Y, Cui A, Arthanari H, Dempsey D
Methods Enzymol
. 2023 Mar;
682:289-318.
PMID: 36948705
Phosphatase and tensin homolog is a lipid phosphatase that serves as the major negative regulator of the PI3K/AKT pathway. It catalyzes the 3'-specific dephosphorylation of phosphatidylinositol (3,4,5)-trisphosphate (PIP) to generate...
3.
Hill S, Esquivel A, Ospina S, Rahal L, Dickey C, Blair L
Protein Sci
. 2022 Oct;
31(11):e4448.
PMID: 36305768
Tauopathies, such as Alzheimer's disease, are characterized by the misfolding and progressive accumulation of the microtubule associated protein tau. Chaperones, tasked with maintaining protein homeostasis, can become imbalanced with age...
4.
Criado-Marrero M, Blazier D, Gould L, Gebru N, Ospina S, Armendariz D, et al.
Sci Rep
. 2022 May;
12(1):7372.
PMID: 35513476
Tau accumulation and progressive loss of neurons are associated with Alzheimer's disease (AD). Aggregation of tau has been associated with endoplasmic reticulum (ER) stress and the activation of the unfolded...
5.
Ospina S, Blazier D, Criado-Marrero M, Gould L, Gebru N, Beaulieu-Abdelahad D, et al.
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35055033
The microtubule-associated protein tau pathologically accumulates and aggregates in Alzheimer's disease (AD) and other tauopathies, leading to cognitive dysfunction and neuronal loss. Molecular chaperones, like small heat-shock proteins (sHsps), can...
6.
Baker J, Ozsan I, Ospina S, Gulick D, Blair L
Int J Mol Sci
. 2018 Dec;
20(1).
PMID: 30585227
The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response. Dysregulation of this neuroendocrine system is a common feature among psychiatric disorders. Steroid hormone receptors, like glucocorticoid receptor (GR), function as...
7.
Dempsey D, Nichols D, Battistini M, Pemberton O, Ospina S, Zhang X, et al.
Sci Rep
. 2017 Oct;
7(1):13432.
PMID: 29044148
Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an ordered sequential...
8.
Dempsey D, Carpenter A, Ospina S, Merkler D
Insect Biochem Mol Biol
. 2015 Oct;
66:1-12.
PMID: 26476413
Arylalkylamine N-acyltransferase like 2 (AANATL2) catalyzes the formation of N-acylarylalkylamides from the corresponding acyl-CoA and arylalkylamine. The N-acylation of biogenic amines in Drosophila melanogaster is a critical step for the...
9.
Dempsey D, Bond J, Carpenter A, Ospina S, Merkler D
Protein Expr Purif
. 2014 Mar;
97:23-8.
PMID: 24576660
Glycine N-acyltransferase (GLYAT) is a phase II metabolic detoxification enzyme for exogenous (xenobiotic) and endogenous carboxylic acids; consisting of fatty acids, benzoic acid, and salicylic acid. GLYAT catalyzes the formation...