Sanna Toivonen
Overview
Explore the profile of Sanna Toivonen including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
403
Followers
0
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Recent Articles
1.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu B, Marin-Canas S, Salpea P, et al.
Diabetologia
. 2023 Mar;
66(7):1306-1321.
PMID: 36995380
Aims/hypothesis: Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing...
2.
Fantuzzi F, Toivonen S, Schiavo A, Chae H, Tariq M, Sawatani T, et al.
Front Cell Dev Biol
. 2022 Sep;
10:967765.
PMID: 36060810
differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function and in humanized...
3.
Igoillo-Esteve M, Oliveira A, Cosentino C, Fantuzzi F, Demarez C, Toivonen S, et al.
JCI Insight
. 2019 Dec;
5(2).
PMID: 31877117
Friedreich ataxia is an autosomal recessive neurodegenerative disease associated with a high diabetes prevalence. No treatment is available to prevent or delay disease progression. Friedreich ataxia is caused by intronic...
4.
Oshima M, Pechberty S, Bellini L, Gopel S, Campana M, Rouch C, et al.
Diabetologia
. 2019 Dec;
63(2):395-409.
PMID: 31796987
Aims/hypothesis: During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion by insulin-producing pancreatic beta cells. The majority...
5.
Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat J, Demine S, et al.
Nucleic Acids Res
. 2018 Sep;
46(19):10302-10318.
PMID: 30247717
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability. Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase,...
6.
Cnop M, Toivonen S, Igoillo-Esteve M, Salpea P
Mol Metab
. 2017 Sep;
6(9):1024-1039.
PMID: 28951826
Background: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important...
7.
Toivonen S, Malinen M, Kublbeck J, Petsalo A, Urtti A, Honkakoski P, et al.
Tissue Eng Part A
. 2016 Jun;
22(13-14):971-84.
PMID: 27329070
Human-induced pluripotent stem cell (hiPSC)-derived hepatocytes are anticipated as important surrogates for primary human hepatocytes in applications ranging from basic research to drug discovery and regenerative medicine. Although methods for...
8.
Tamminen K, Balboa D, Toivonen S, Pakarinen M, Wiener Z, Alitalo K, et al.
PLoS One
. 2015 Aug;
10(7):e0134551.
PMID: 26230325
Wnt/beta-catenin signaling plays a central role in guiding the differentiation of the posterior parts of the primitive gut tube into intestinal structures in vivo and some studies suggest that FGF4...
9.
Asikainen S, Heikkinen L, Juhila J, Holm F, Weltner J, Trokovic R, et al.
PLoS One
. 2015 Mar;
10(3):e0116668.
PMID: 25822230
Small RNA molecules, including microRNAs (miRNAs), play critical roles in regulating pluripotency, proliferation and differentiation of embryonic stem cells. miRNA-offset RNAs (moRNAs) are similar in length to miRNAs, align to...
10.
Hakonen E, Toivonen S, Jalanko H, Otonkoski T
Duodecim
. 2015 Jan;
130(19):1973-80.
PMID: 25558618
The pancreas and the liver are developmentally closely connected with each other.The development of stem cell technology has enabled the production of functional pancreatic endocrine cells and hepatocytes from pluripotent...