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Sandro L Pereira

Explore the profile of Sandro L Pereira including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 702
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Recent Articles
11.
Borsche M, Pereira S, Klein C, Grunewald A
J Parkinsons Dis . 2020 Oct; 11(1):45-60. PMID: 33074190
Mitochondrial dysfunction represents a well-established player in the pathogenesis of both monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation that mitochondrial toxins cause PD, findings from genetic...
12.
Borsche M, Konig I, Delcambre S, Petrucci S, Balck A, Bruggemann N, et al.
Brain . 2020 Oct; 143(10):3041-3051. PMID: 33029617
There is increasing evidence for a role of inflammation in Parkinson's disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the...
13.
Delcambre S, Ghelfi J, Ouzren N, Grandmougin L, Delbrouck C, Seibler P, et al.
Front Neurol . 2020 Sep; 11:881. PMID: 32982917
Several mutations in leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. Yet,...
14.
Rodrigues A, Pereira S, Ramalho-Santos J
Biochim Biophys Acta Mol Basis Dis . 2020 Mar; 1866(7):165760. PMID: 32151634
Metabolism, is a transversal hot research topic in different areas, resulting in the integration of cellular needs with external cues, involving a highly coordinated set of activities in which nutrients...
15.
Correia M, Sousa M, Rodrigues A, Perestrelo T, Pereira S, Ribeiro M, et al.
Data Brief . 2016 Oct; 7:1190-1195. PMID: 27761502
The use of new compounds as dietary supplements is increasing, but little is known in terms of possible consequences of their use. Pluripotent stem cells are a promising research tool...
16.
Correia M, Perestrelo T, Rodrigues A, Ribeiro M, Pereira S, Sousa M, et al.
Biochim Biophys Acta Gen Subj . 2016 Sep; 1861(1 Pt A):3444-3455. PMID: 27614149
Background: Pluripotent stem cells promise innovative approaches for enduring diseases, including disease modeling and drug screens. Accordingly, efforts have been undertaken in order to efficiently reprogram somatic cells to pluripotency,...
17.
Correia M, Rodrigues A, Perestrelo T, Pereira S, Ribeiro M, Sousa M, et al.
Food Chem Toxicol . 2015 Dec; 87:148-56. PMID: 26683311
Kaempferol (3,4',5,7-tetrahydroxyflavone) is a natural flavonoid with several beneficial and protective effects. It has been demonstrated that kaempferol has anticancer properties, particularly due to its effects on proliferation, apoptosis and...
18.
Rodrigues A, Pereira S, Correia M, Gomes A, Perestrelo T, Ramalho-Santos J
PLoS One . 2015 Aug; 10(8):e0135617. PMID: 26266544
Background: Pluripotent embryonic stem cells grown under standard conditions (ESC) have a markedly glycolytic profile, which is shared with many different types of cancer cells. Thus, some therapeutic strategies suggest...
19.
Rodrigues A, Correia M, Gomes A, Pereira S, Perestrelo T, Sousa M, et al.
PLoS One . 2015 Jul; 10(7):e0131663. PMID: 26147621
Introduction: The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions...
20.
Pereira S, Rodrigues A, Sousa M, Correia M, Perestrelo T, Ramalho-Santos J
Hum Reprod Update . 2014 Jul; 20(6):924-43. PMID: 25013216
Background: Both pluripotent stem cells (PSCs) and cancer cells have been described as having similar metabolic pathways, most notably a penchant for favoring glycolysis even under aerobiosis, suggesting common themes...