Sandra P Welch
Overview
Explore the profile of Sandra P Welch including associated specialties, affiliations and a list of published articles.
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23
Citations
510
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Recent Articles
1.
Sim-Selley L, Wilkerson J, Burston J, Hauser K, McLane V, Welch S, et al.
J Pharmacol Exp Ther
. 2018 Jun;
366(3):509-518.
PMID: 29945931
The immunomodulatory prodrug 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol (FTY720), which acts as an agonist for sphingosine-1-phosphate (S1P) receptors (S1PR) when phosphorylated, is proposed as a novel pain therapeutic. In this study, we assessed FTY720-mediated...
2.
Selley D, Welch S, Sim-Selley L
Life Sci
. 2013 Jun;
93(5-6):187-93.
PMID: 23782998
A significant number of patients experience chronic pain and the intractable side effects of currently prescribed pain medications. Recent evidence indicates important pain-modulatory roles for two classes of G-protein-coupled receptors...
3.
Welch S, Sim-Selley L, Selley D
Biochem Pharmacol
. 2012 Sep;
84(12):1551-62.
PMID: 22971335
Lysolipids are important mediators of cellular communication in multiple physiological processes. Sphingosine-1-phosphate (S1P) is a major lysolipid in many organs, including the central nervous system (CNS). This commentary discusses recent...
4.
Zou S, Fitting S, Hahn Y, Welch S, El-Hage N, Hauser K, et al.
Brain
. 2011 Nov;
134(Pt 12):3616-31.
PMID: 22102648
Individuals infected with human immunodeficiency virus-1 who abuse opiates can have a higher incidence of virus-associated neuropathology. Human immunodeficiency virus does not infect neurons, but viral proteins such as transactivator...
5.
Sim-Selley L, Goforth P, Mba M, Macdonald T, Lynch K, Milstien S, et al.
J Neurochem
. 2009 Jun;
110(4):1191-202.
PMID: 19493165
Sphingosine-1-phosphate (S1P) is a ubiquitous, lipophilic cellular mediator that acts in part by activation of G-protein-coupled receptor. Modulation of S1P signaling is an emerging pharmacotherapeutic target for immunomodulatory drugs. Although...
6.
Welch S
Int Rev Psychiatry
. 2009 Apr;
21(2):143-51.
PMID: 19367508
Cannabinoids and opioids produce antinociceptive synergy. Cannabinoids such as Delta-9-tetrahydrocannabinol (THC) release endogenous opioids and endocannabinoids such as anandamide (AEA) also alter endogenous opioid tone. Opioids and cannabinoids bind distinct...
7.
Haller V, Stevens D, Welch S
Eur J Pharmacol
. 2008 Sep;
600(1-3):50-8.
PMID: 18762181
Lack of involvement of the opioid system with the endocannabinoid, arachidonylethanolamide (anandamide) was possibly due to hydrolysis by fatty acid amide hydrolase (FAAH). Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597) is an...
8.
Williams J, Haller V, Stevens D, Welch S
Eur J Pharmacol
. 2008 Mar;
584(1):78-86.
PMID: 18313663
We have previously demonstrated synergy between morphine and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in the expression of antinociception in acute pain models and in arthritic models of chronic pain. Our data has been...
9.
Kren M, Haller V, Welch S
Eur J Pharmacol
. 2007 Dec;
578(2-3):177-84.
PMID: 18054782
The purpose of this study was to evaluate the effects of the gonadal hormones on the opioid receptor protein levels of Freund's adjuvant-treated (arthritic) male and female Lewis rats. Following...
10.
Haller V, Bernstein M, Welch S
Eur J Pharmacol
. 2007 Dec;
578(2-3):101-7.
PMID: 18048029
Voltage-gated L- and N-type calcium channels (VOCs) are implicated in the activity of morphine, but their contribution to the expression of opioid tolerance remains uncertain. L- and N-type VOCs are...