Sandra M Sacre
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Explore the profile of Sandra M Sacre including associated specialties, affiliations and a list of published articles.
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15
Citations
425
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Recent Articles
1.
Clanchy F, Borghese F, Bystrom J, Balog A, Penn H, Hull D, et al.
J Autoimmun
. 2021 Jan;
118:102597.
PMID: 33493980
The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution...
2.
Alberts B, Barber J, Sacre S, Davies K, Ghezzi P, Mullen L
J Rheumatol
. 2019 Mar;
46(9):1141-1150.
PMID: 30824640
Objective: To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to...
3.
Alberts B, Sacre S, Bush P, Mullen L
J Cell Mol Med
. 2018 Nov;
23(2):1617-1621.
PMID: 30450736
Tissue inhibitor of metalloproteinase (TIMP)-3 is a natural inhibitor of a range of enzymes that degrade connective tissue and are involved in the pathogenesis of conditions such as arthritis and...
4.
Clanchy F, Sacre S
Expert Opin Biol Ther
. 2010 Nov;
10(12):1703-16.
PMID: 21039312
Importance Of The Field: The role of toll-like receptors (TLRs) in the immune response to exogenous pathogens is well characterized. These receptors have been suggested to be involved in the...
5.
Drexler S, Sacre S, Foxwell B
Expert Rev Clin Immunol
. 2010 May;
2(4):585-99.
PMID: 20477615
Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases. It is characterized by chronic inflammation of the joint leading to its destruction. Although the initiating cause remains elusive,...
6.
Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al.
J Immunol
. 2008 Nov;
181(11):8002-9.
PMID: 19017992
The advent of anti-TNF biologicals has been a seminal advance in the treatment of rheumatoid arthritis (RA) and has confirmed the important role of TNF in disease pathogenesis. However, it...
7.
Sacre S, Drexler S, Andreakos E, Feldmann M, Brennan F, Foxwell B
Ann Rheum Dis
. 2007 Nov;
66 Suppl 3:iii81-6.
PMID: 17934103
In the last decade the development of a number of biological therapies has revolutionised the treatment of rheumatic diseases. The first and most widely used of these approaches, tumour necrosis...
8.
Lundberg A, Drexler S, Monaco C, Williams L, Sacre S, Feldmann M, et al.
Blood
. 2007 Jul;
110(9):3245-52.
PMID: 17660379
TLR3 recognizes double-stranded RNA, a product associated with viral infections. Many details of TLR3-induced mechanisms have emerged from gene-targeted mice or inhibition studies in transformed cell lines. However, the pathways...
9.
Sacre S, Lundberg A, Andreakos E, Taylor C, Feldmann M, Foxwell B
J Immunol
. 2007 Feb;
178(4):2148-54.
PMID: 17277119
TLR signal via Toll-IL-1R (TIR) homology domain-containing adaptor proteins. One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-beta-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling...
10.
Sacre S, Andreakos E, Kiriakidis S, Amjadi P, Lundberg A, Giddins G, et al.
Am J Pathol
. 2007 Jan;
170(2):518-25.
PMID: 17255320
The widespread distribution of Toll-like receptors (TLRs) and their ligands raises the question whether they contribute to the production of inflammatory and tissue destructive molecules in rheumatoid arthritis (RA). We...