Sandra Holzhauer
Overview
Explore the profile of Sandra Holzhauer including associated specialties, affiliations and a list of published articles.
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7
Citations
128
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0
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Recent Articles
1.
Kudek M, Xin G, Alson D, Holzhauer S, Shen J, Kasmani M, et al.
J Immunol
. 2023 Mar;
210(9):1281-1291.
PMID: 36920384
Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In...
2.
Gu J, Wang C, Cao C, Huang J, Holzhauer S, Desilva H, et al.
Oncoimmunology
. 2021 Aug;
10(1):1941566.
PMID: 34350062
Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells. A direct comparison of tumor growth...
3.
Gerbec Z, Hashemi E, Nanbakhsh A, Holzhauer S, Yang C, Mei A, et al.
iScience
. 2020 Aug;
23(9):101454.
PMID: 32858341
During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found activation of NK...
4.
Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese M, Zheng Y, Wang D, et al.
Cancer Immunol Res
. 2019 Sep;
7(10):1647-1662.
PMID: 31515257
Natural killer (NK) cells generate proinflammatory cytokines that are required to contain infections and tumor growth. However, the posttranscriptional mechanisms that regulate NK cell functions are not fully understood. Here,...
5.
Jing W, Gershan J, Holzhauer S, Weber J, Palen K, McOlash L, et al.
Cancer Res
. 2017 Sep;
77(20):5676-5686.
PMID: 28916658
Efforts to improve the efficacy of adoptive T-cell therapies and immune checkpoint therapies in myelogenous leukemia are desired. In this study, we evaluated the antileukemia activity of adoptively transferred polyclonal...
6.
Pritchard Jr K, Ou J, Ou Z, Shi Y, Franciosi J, Signorino P, et al.
Am J Physiol Lung Cell Mol Physiol
. 2003 Sep;
286(4):L705-14.
PMID: 12972407
Vaso-occlusive events are the major source of morbidity and mortality in sickle cell disease (SCD); however, the pathogenic mechanisms driving these events remain unclear. Using hypoxia to induce pulmonary injury,...
7.
Ou J, Ou Z, Jones D, Holzhauer S, Hatoum O, Ackerman A, et al.
Circulation
. 2003 May;
107(18):2337-41.
PMID: 12732610
Background: Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state...