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Sandhya Prabhakaran

Explore the profile of Sandhya Prabhakaran including associated specialties, affiliations and a list of published articles. Areas
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Articles 18
Citations 1349
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Recent Articles
1.
Nowicka Z, Rentzeperis F, Tagal V, Teer J, Ilter D, Beck R, et al.
Cancer Res . 2025 Feb; PMID: 39933186
Glioblastoma (GBM) is the most aggressive form of primary brain tumor. The infiltrative nature of GBM makes complete surgical resection impossible. The selective forces that govern gliomagenesis are strong, shaping...
2.
Prabhakaran S, Yapp C, Baker G, Beyer J, Chang Y, Creason A, et al.
Mol Oncol . 2025 Feb; PMID: 39927650
The National Cancer Institute (NCI) supports numerous research consortia that rely on imaging technologies to study cancerous tissues. To foster collaboration and innovation in this field, the Image Analysis Working...
3.
Alahmari S, Schultz A, Albrecht J, Tagal V, Siddiqui Z, Prabhakaran S, et al.
bioRxiv . 2024 Sep; PMID: 39282313
Several methods for cell cycle inference from sequencing data exist and are widely adopted. In contrast, methods for classification of cell cycle state from imaging data are scarce. We have...
4.
Onubogu U, Gatenbee C, Prabhakaran S, Wolfe K, Oakes B, Salatino R, et al.
JCI Insight . 2024 May; 9(12). PMID: 38805346
Tumor evolution is driven by genetic variation; however, it is the tumor microenvironment (TME) that provides the selective pressure contributing to evolution in cancer. Despite high histopathological heterogeneity within glioblastoma...
5.
Desai B, Miti T, Prabhakaran S, Miroshnychenko D, Henry M, Marusyk V, et al.
bioRxiv . 2024 May; PMID: 38712093
Targeted therapies directed against oncogenic signaling addictions, such as inhibitors of ALK in ALK+ NSCLC often induce strong and durable clinical responses. However, they are not curative in metastatic cancers,...
6.
Nowicka Z, Rentzeperis F, Beck R, Tagal V, Pinto A, Scanu E, et al.
bioRxiv . 2023 Oct; PMID: 37905142
Glioblastoma (GBM) is the most aggressive form of primary brain tumor. Complete surgical resection of GBM is almost impossible due to the infiltrative nature of the cancer. While no evidence...
7.
Prabhakaran S, Yapp C, Baker G, Beyer J, Chang Y, Creason A, et al.
bioRxiv . 2023 Aug; PMID: 37547011
The National Cancer Institute (NCI) supports many research programs and consortia, many of which use imaging as a major modality for characterizing cancerous tissue. A trans-consortia Image Analysis Working Group...
8.
Gatenbee C, Baker A, Prabhakaran S, Swinyard O, Slebos R, Mandal G, et al.
Nat Commun . 2023 Jul; 14(1):4502. PMID: 37495577
Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and access to technology. An alternative approach is...
9.
Goncalves I, Hormuth 2nd D, Prabhakaran S, Phillips C, Garcia-Aznar J
GigaByte . 2023 Mar; 2023:gigabyte77. PMID: 36949818
models of biological systems are usually very complex and rely on a large number of parameters describing physical and biological properties that require validation. As such, parameter space exploration is...
10.
Prabhakaran S
Bioinform Adv . 2023 Jan; 2(1):vbac048. PMID: 36699413
Motivation: Imaging-based spatial transcriptomics has the power to reveal patterns of single-cell gene expression by detecting mRNA transcripts as individually resolved spots in multiplexed images. However, molecular quantification has been...