Samuel R McKee
Overview
Explore the profile of Samuel R McKee including associated specialties, affiliations and a list of published articles.
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7
Citations
93
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Recent Articles
1.
Berida T, Huang T, Weck S, Lutz M, McKee S, Kagerah N, et al.
bioRxiv
. 2025 Feb;
PMID: 39975250
Abstract Figure:
2.
Georgiades J, Berkovich D, McKee S, Smith A, Sankaran B, Flentie K, et al.
ACS Infect Dis
. 2025 Feb;
11(3):689-702.
PMID: 39950956
Antibiotics that operate multiple mechanisms of action are a promising strategy to combat growing resistance. Previous studies have shown that dual action antifolates formed from a pyrroloquinazolinediamine core can inhibit...
3.
Sur Chowdhury C, Kinsella R, McNehlan M, Naik S, Lane D, Talukdar P, et al.
Cell Host Microbe
. 2024 Dec;
32(12):2092-2111.e7.
PMID: 39637864
Neutrophils are the most abundant cell type in the airways of tuberculosis patients. Mycobacterium tuberculosis (Mtb) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and...
4.
Naik S, McNehlan M, Mreyoud Y, Kinsella R, Smirnov A, Sur Chowdhury C, et al.
Mucosal Immunol
. 2024 Jul;
17(5):1114-1127.
PMID: 39038752
Polymorphisms in the IRGM gene are associated with susceptibility to tuberculosis in humans. A murine ortholog of Irgm, Irgm1, is also essential for controlling Mycobacterium tuberculosis (Mtb) infection in mice....
5.
Feng S, McNehlan M, Kinsella R, Sur Chowdhury C, Chavez S, Naik S, et al.
Nat Microbiol
. 2024 Feb;
9(3):684-697.
PMID: 38413834
Although autophagy sequesters Mycobacterium tuberculosis (Mtb) in in vitro cultured macrophages, loss of autophagy in macrophages in vivo does not result in susceptibility to a standard low-dose Mtb infection until...
6.
Naik S, McNehlan M, Mreyoud Y, Kinsella R, Smirnov A, Sur Chowdhury C, et al.
bioRxiv
. 2023 Oct;
PMID: 37873329
Polymorphisms in the gene are associated with susceptibility to tuberculosis in humans. A murine ortholog of , , is also essential for controlling (Mtb) infection in mice. Multiple processes have...
7.
Berida T, McKee S, Chatterjee S, Manning D, Li W, Pandey P, et al.
ACS Infect Dis
. 2023 Oct;
9(11):2282-2298.
PMID: 37788674
The rise in multidrug resistant tuberculosis cases underscores the urgent need to develop new treatment strategies for tuberculosis. Herein, we report the discovery and synthesis of a new series of...
8.
Sarkar S, Mayer Bridwell A, Good J, Wang E, McKee S, Valenta J, et al.
J Med Chem
. 2023 Jul;
66(16):11056-11077.
PMID: 37485869
() drug resistance poses an alarming threat to global tuberculosis control. We previously reported that , a ring-fused thiazolo-2-pyridone, inhibits respiration, blocks biofilm formation, and restores the activity of the...
9.
Feldman M, Mayer Bridwell A, Scott N, Vinogradov E, McKee S, Chavez S, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18655-18663.
PMID: 31455739
Hypervirulent (hv) is globally disseminating as a community-acquired pathogen causing life-threatening infections in healthy individuals. The fact that a dose as little as 50 bacteria is lethal to mice illustrates...