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Samantha F H De Witte

Explore the profile of Samantha F H De Witte including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
De Witte S, Peters F, Merino A, Korevaar S, van Meurs J, OFlynn L, et al.
Cytotherapy . 2018 Jun; 20(7):919-929. PMID: 29934259
Background: Mesenchymal stromal cells (MSCs) are studied for their immunotherapeutic potential. Prior to therapeutic use, MSCs are culture expanded to obtain the required cell numbers and, to improve their efficacy,...
2.
De Witte S, Luk F, Sierra Parraga J, Gargesha M, Merino A, Korevaar S, et al.
Stem Cells . 2018 Jan; 36(4):602-615. PMID: 29341339
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential immunotherapy. MSC are usually administered via intravenous infusion, after which they are trapped in the lungs and die...
3.
Luk F, Carreras-Planella L, Korevaar S, De Witte S, Borras F, Betjes M, et al.
Front Immunol . 2017 Sep; 8:1042. PMID: 28894451
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. The effects of MSC on B cells...
4.
De Witte S, Merino A, Franquesa M, Strini T, van Zoggel J, Korevaar S, et al.
Stem Cell Res Ther . 2017 Jun; 8(1):140. PMID: 28595619
Background: Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeting...
5.
De Witte S, Lambert E, Merino A, Strini T, Douben H, OFlynn L, et al.
Cytotherapy . 2017 May; 19(7):798-807. PMID: 28462821
Background Aims: Mesenchymal stromal cells (MSCs) are used as experimental immunotherapy. Extensive culture expansion is necessary to obtain clinically relevant cell numbers, although the impact on MSCs stability and function...
6.
Grotenhuis N, De Witte S, van Osch G, Bayon Y, Lange J, Bastiaansen-Jenniskens Y
Tissue Eng Part A . 2016 Aug; 22(17-18):1098-107. PMID: 27520733
Background: Macrophages and mesenchymal stem cells (MSCs) are important cells in wound healing. We hypothesized that the cross-talk between macrophages and adipose tissue-derived MSCs (ASCs) is biomaterial dependent, thereby influencing...
7.
Luk F, De Witte S, Korevaar S, Roemeling-van Rhijn M, Franquesa M, Strini T, et al.
Stem Cells Dev . 2016 Jun; 25(18):1342-54. PMID: 27349989
Mesenchymal stem cells (MSC) are studied as a cell therapeutic agent for treatment of various immune diseases. However, therapy with living culture-expanded cells comes with safety concerns. Furthermore, development of...
8.
Hoogduijn M, De Witte S, Luk F, van den Hout-van Vroonhoven M, Ignatowicz L, Catar R, et al.
Stem Cells Dev . 2016 Feb; 25(8):586-97. PMID: 26914168
Mesenchymal stromal cells (MSC) are increasingly used as an investigative therapeutic product for immune disorders and degenerative disease. Typically, MSC are isolated from human tissue, expanded in culture, and cryopreserved...
9.
De Witte S, Franquesa M, Baan C, Hoogduijn M
Front Immunol . 2016 Jan; 6:648. PMID: 26779185
Mesenchymal stem cells (MSC) are under development as an immunomodulatory therapy. The anticipated immunomodulatory effects of MSC are broad, from direct inhibition of lymphocyte proliferation, induction of regulatory T and...
10.
Luk F, De Witte S, Bramer W, Baan C, Hoogduijn M
Expert Rev Clin Immunol . 2015 Mar; 11(5):617-36. PMID: 25817052
Mesenchymal stem cells (MSC) are widely studied for their immunomodulatory properties. Data from in vitro and pre-clinical models demonstrate that MSC suppress activated immune cells and ameliorate the severity of...