Samantha C Faber
Overview
Explore the profile of Samantha C Faber including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
142
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0
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Recent Articles
1.
Shinozawa T, Miyamoto K, Baker K, Faber S, Flores R, Uetrecht J, et al.
Toxicol Sci
. 2025 Jan;
PMID: 39786842
The frequency of drug-induced liver injury (DILI) in clinical trials remains a challenge for drug developers despite advances in human hepatotoxicity models and improvements in reducing liver-related attrition in preclinical...
2.
Faber S, Lahoti T, Taylor E, Lewis L, Sapiro J, Sales V, et al.
Cells
. 2022 May;
11(10).
PMID: 35626744
Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within and beyond the GI tract. The ubiquitous expression...
3.
Faber S, Giani Tagliabue S, Bonati L, Denison M
Int J Mol Sci
. 2020 Jun;
21(11).
PMID: 32526934
1,2-naphthoquinone (1,2-NQ) and 1,4-naphthoquinone (1,4-NQ) are clinically promising biologically active chemicals that have been shown to stimulate the aryl hydrocarbon receptor (AhR) signaling pathway, but whether they are direct or...
4.
Faber S, McNabb N, Ariel P, Aungst E, McCullough S
Toxicol Sci
. 2020 Jun;
177(1):140-155.
PMID: 32525552
In vitro bronchial epithelial monoculture models have been pivotal in defining the adverse effects of inhaled toxicant exposures; however, they are only representative of one cellular compartment and may not...
5.
Faber S, McCullough S
Appl In Vitro Toxicol
. 2019 Aug;
4(2):115-128.
PMID: 31380467
With 7 million deaths reported annually from air pollution alone, it is evident that adverse effects of inhaled toxicant exposures remain a major public health concern in the 21st century....
6.
Giani Tagliabue S, Faber S, Motta S, Denison M, Bonati L
Sci Rep
. 2019 Jul;
9(1):10693.
PMID: 31337850
The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results...
7.
Faber S, Soshilov A, Giani Tagliabue S, Bonati L, Denison M
Int J Mol Sci
. 2018 Sep;
19(9).
PMID: 30201897
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that modulates gene expression following its binding and activation by structurally diverse chemicals. Species differences in AhR functionality have been...
8.
Denison M, Faber S
Curr Opin Toxicol
. 2017 Aug;
2:124-131.
PMID: 28845473
Ligand-dependent activation of the Ah receptor (AhR) can result in an extremely diverse spectrum of biological and toxic effects that occur in a ligand-, species- and tissue-specific manner. While the...