Sam Spijkers-Shaw
Overview
Explore the profile of Sam Spijkers-Shaw including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
6
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Recent Articles
1.
Spijkers-Shaw S, Devlin R, Shields N, Feng X, Peck T, Lenihan-Geels G, et al.
Angew Chem Int Ed Engl
. 2024 Feb;
63(13):e202316791.
PMID: 38308859
Heparin and heparan sulfate (HS) are naturally occurring mammalian glycosaminoglycans, and their synthetic and semi-synthetic mimetics have attracted significant interest as potential therapeutics. However, understanding the mechanism of action by...
2.
Peck T, Davis C, Lenihan-Geels G, Griffiths M, Spijkers-Shaw S, Zubkova O, et al.
J Neuroinflammation
. 2023 Nov;
20(1):251.
PMID: 37915090
Background: Disruption of the extracellular matrix at the blood-brain barrier (BBB) underpins neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix components, such as heparan sulfate (HS) proteoglycans, can...
3.
Spijkers-Shaw S, Campbell K, Shields N, Miller J, Rendle P, Jiao W, et al.
Chem Asian J
. 2022 Apr;
17(12):e202200228.
PMID: 35427432
Heparan sulfate (HS) is a highly sulfated natural carbohydrate that plays crucial roles in cancer, inflammation, and angiogenesis. Heparanase (HPSE) is the sole HS degrading endoglycosidase that cleaves HS at...