Sam Okret
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Explore the profile of Sam Okret including associated specialties, affiliations and a list of published articles.
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33
Citations
516
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Recent Articles
1.
Yao H, Chen X, Wang T, Kashif M, Qiao X, Tuksammel E, et al.
Cell Rep
. 2023 Aug;
42(8):112961.
PMID: 37561633
Refractory and relapsed B cell lymphomas are often driven by the difficult-to-target oncogene MYC. Here, we report that high MYC expression stimulates proliferation and protects B lymphoma cells from apoptosis...
2.
Huang D, Berglund M, Damdimopoulos A, Antonson P, Lindskog C, Enblad G, et al.
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831639
For most lymphomas, including diffuse large B-cell lymphoma (DLBCL), the male incidence is higher, and the prognosis is worse compared to females. The reasons are unclear; however, epidemiological and experimental...
3.
Huang D, Huang Z, Indukuri R, Bangalore Revanna C, Berglund M, Guan J, et al.
Cancers (Basel)
. 2022 Jul;
14(13).
PMID: 35804870
Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with one of the highest male-to-female incidence ratios. The reason for this is not clear, but epidemiological as well as experimental data...
4.
Yakimchuk K, Bangalore Revanna C, Huang D, Inzunza J, Okret S
Endocr Connect
. 2018 Nov;
7(12):1472-1479.
PMID: 30496125
Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors α (ESR1) and β (ESR2). With regard to hematological malignancies, expression of ESR2 has been found in both B...
5.
Guan J, Huang D, Yakimchuk K, Okret S
Mol Cancer Ther
. 2018 Feb;
17(5):1090-1100.
PMID: 29483220
Acquired resistance to cancer drugs is common, also for modern targeted drugs like the Bruton tyrosine kinase (BTK) inhibitor ibrutinib, a new drug approved for the treatment of the highly...
6.
Sharif Hasni M, Berglund M, Yakimchuk K, Guan J, Linderoth J, Amini R, et al.
Leuk Lymphoma
. 2016 Jul;
58(2):418-427.
PMID: 27357538
Diffuse large B-cell lymphoma (DLBCL) shows a higher incidence in males versus females. Epidemiological studies have shown that female gender is a favorable prognostic factor, which may be explained by...
7.
Talaber G, Yakimchuk K, Guan J, Inzunza J, Okret S
Oncotarget
. 2016 Mar;
7(15):20718-27.
PMID: 26943574
Most lymphomas show higher incidence and poorer prognosis in males compared to females. However, the endocrine contribution to this gender difference is not entirely known. Here we show that castration...
8.
Talaber G, Jondal M, Okret S
Steroids
. 2015 Jun;
103:58-63.
PMID: 26102271
Besides generating immunocompetent T lymphocytes, the thymus is an established site of de novo extra-adrenal glucocorticoid (GC) production. Among the compartments of the thymus, both stromal thymic epithelial cells (TECs)...
9.
Talaber G, Tuckermann J, Okret S
FASEB J
. 2015 Mar;
29(6):2526-34.
PMID: 25733567
It has been known for decades that lowering the circulating glucocorticoid (GC) concentration as in Addison's disease or after removing the adrenals results in thymus enlargement, largely due to thymocyte...
10.
Yakimchuk K, Chen L, Hasni M, Okret S, Jondal M
Autoimmunity
. 2014 Nov;
48(2):117-24.
PMID: 25401790
Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims...