Sam Kint
Overview
Explore the profile of Sam Kint including associated specialties, affiliations and a list of published articles.
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9
Citations
100
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Recent Articles
1.
Kiviaho A, Eerola S, Kallio H, Andersen M, Hoikka M, Tiihonen A, et al.
Nat Commun
. 2024 Nov;
15(1):9949.
PMID: 39550375
Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation toward...
2.
Franken A, Bila M, Mechels A, Kint S, Van Dessel J, Pomella V, et al.
Immunity
. 2024 Mar;
57(3):541-558.e7.
PMID: 38442708
Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell...
3.
Sloan A, Silver D, Kint S, Gallo M, Lathia J
Neuro Oncol
. 2024 Feb;
26(5):785-795.
PMID: 38394444
Over the past 2 decades, the cancer stem cell (CSC) hypothesis has provided insight into many malignant tumors, including glioblastoma (GBM). Cancer stem cells have been identified in patient-derived tumors...
4.
Pozniak J, Pedri D, Landeloos E, Van Herck Y, Antoranz A, Vanwynsberghe L, et al.
Cell
. 2024 Jan;
187(1):166-183.e25.
PMID: 38181739
To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established a comprehensive view of the cellular architecture of the treatment-naive melanoma ecosystem and studied its evolution under ICB....
5.
Kint S, Van Criekinge W, Vandekerckhove L, De Vos W, Bomsztyk K, Krause D, et al.
Nucleic Acids Res
. 2021 Jan;
49(8):e43.
PMID: 33511400
Characterization of the epigenetic status of individual cells remains a challenge. Current sequencing approaches have limited coverage, and it is difficult to assign an epigenetic status to the transcription state...
6.
Kint S, Trypsteen W, De Spiegelaere W, Malatinkova E, Kinloch-De Loes S, De Meyer T, et al.
Clin Epigenetics
. 2020 Mar;
12(1):36.
PMID: 32111236
Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved...
7.
Rutsaert S, Steens J, Gineste P, Cole B, Kint S, Barrett P, et al.
J Virus Erad
. 2019 Feb;
5(1):10-22.
PMID: 30800421
Objectives: To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Methods: Randomised, double-blind,...
8.
Kint S, De Spiegelaere W, De Kesel J, Vandekerckhove L, Van Criekinge W
PLoS One
. 2018 Jun;
13(6):e0199091.
PMID: 29902267
DNA methylation is one of the most important epigenetic modifications in the regulation of gene transcription. The current gold standard to study this modification is bisulfite sequencing. Although multiple commercial...
9.
Kint S, Van Hecke C, Cole B, Vandekerckhove L, Sips M
J Virus Erad
. 2018 Mar;
4(1):55-58.
PMID: 29568556
For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular...