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Sam Hart

Explore the profile of Sam Hart including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 283
Followers 0
Related Specialties
Biochemistry
Chemistry
Critical Care
Top 10 Co-Authors
Johan P Turkenburg
Gideon Grogan
Irene J Higginson
Eli Silber
Rachel Burman
Polly Edmonds
Adrian C Whitwood
Nicholas J Turner
Neil C Bruce
Tariq Saleem
Published In
Chembiochem
BMC Palliat Care
Nat Commun
J Mol Biol
J Am Chem Soc
Affiliations
Soon will be listed here.
Recent Articles
1.
Cryo-EM structure of the CDK2-cyclin A-CDC25A complex
Rowland R, Korolchuk S, Salamina M, Tatum N, Ault J, Hart S, et al.
Nat Commun . 2024 Aug; 15(1):6807. PMID: 39122719
The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we...
2.
Deciphering complexity in Pd-catalyzed cross-couplings
Clarke G, Firth J, Ledingham L, Horbaczewskyj C, Bourne R, Bray J, et al.
Nat Commun . 2024 May; 15(1):3968. PMID: 38729925
Understanding complex reaction systems is critical in chemistry. While synthetic methods for selective formation of products are sought after, oftentimes it is the full reaction signature, i.e., complete profile of...
3.
Structural analysis of five-coordinate aluminium(salen) complexes and its relationship to their catalytic activity
Fish H, Hart S, Lamb K, North M, Quek S, Whitwood A, et al.
Dalton Trans . 2020 Dec; 50(2):587-598. PMID: 33367409
The crystal structure of [Al(tBu-salen)]2O·HCl shows major changes compared to that of [Al(tBu-salen)]2O. The additional proton is localized on the bridging oxygen atom, making the aluminium atoms more electron deficient....
4.
Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae
Fowler C, Hemsworth G, Cuskin F, Hart S, Turkenburg J, Gilbert H, et al.
Acta Crystallogr D Struct Biol . 2018 Oct; 74(Pt 10):946-955. PMID: 30289404
The biological conversion of lignocellulosic matter into high-value chemicals or biofuels is of increasing industrial importance as the sector slowly transitions away from nonrenewable sources. Many industrial processes involve the...
5.
Structure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-Methylpyrroline
Man H, Wells E, Hussain S, Leipold F, Hart S, Turkenburg J, et al.
Chembiochem . 2015 Mar; 16(7):1052-9. PMID: 25809902
Oxidoreductases from Streptomyces sp. GF3546 [3546-IRED], Bacillus cereus BAG3X2 (BcIRED) and Nocardiopsis halophila (NhIRED) each reduce prochiral 2-methylpyrroline (2MPN) to (S)-2-methylpyrrolidine with >95 % ee and also a number of...
6.
Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution
Jensen C, Mielke T, Farrugia J, Frank A, Man H, Hart S, et al.
Chembiochem . 2015 Mar; 16(6):968-76. PMID: 25737306
The FAD-dependent monooxygenase HbpA from Pseudomonas azelaica HBP1 catalyses the hydroxylation of 2-hydroxybiphenyl (2HBP) to 2,3-dihydroxybiphenyl (23DHBP). HbpA has been used extensively as a model for studying flavoprotein hydroxylases under...
7.
Halogen- and hydrogen-bonded salts and co-crystals formed from 4-halo-2,3,5,6-tetrafluorophenol and cyclic secondary and tertiary amines: orthogonal and non-orthogonal halogen and hydrogen bonding, and synthetic analogues of halogen-bonded...
Takemura A, McAllister L, Hart S, Pridmore N, Karadakov P, Whitwood A, et al.
Chemistry . 2014 May; 20(22):6721-32. PMID: 24796890
Co-crystallisation of, in particular, 4-iodotetrafluorophenol with a series of secondary and tertiary cyclic amines results in deprotonation of the phenol and formation of the corresponding ammonium phenate. Careful examination of...
8.
Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions
Fekete M, Bayfield O, Bayfield O, Duckett S, Hart S, Mewis R, et al.
Inorg Chem . 2013 Nov; 52(23):13453-61. PMID: 24215616
The hyperpolarization (HP) method signal amplification by reversible exchange (SABRE) uses para-hydrogen to sensitize substrate detection by NMR. The catalyst systems [Ir(H)2(IMes)(MeCN)2(R)]BF4 and [Ir(H)2(IMes)(py)2(R)]BF4 [py = pyridine; R = PCy3...
9.
Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate
Rodriguez-Mata M, Frank A, Wells E, Leipold F, Turner N, Hart S, et al.
Chembiochem . 2013 Jul; 14(11):1372-9. PMID: 23813853
NADPH-dependent oxidoreductase Q1EQE0 from Streptomyces kanamyceticus catalyzes the asymmetric reduction of the prochiral monocyclic imine 2-methyl-1-pyrroline to the chiral amine (R)-2-methylpyrrolidine with >99% ee, and is thus of interest as...
10.
Structures of a γ-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP-GABA adduct
Bruce H, Tuan A, Mangas Sanchez J, Leese C, Hopwood J, Hyde R, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun . 2012 Oct; 68(Pt 10):1175-80. PMID: 23027742
Two complex structures of the γ-aminobutyrate (GABA) transaminase A1R958 from Arthrobacter aurescens TC1 are presented. The first, determined to a resolution of 2.80 Å, features the internal aldimine formed by...