Salvador Casani-Galdon
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Explore the profile of Salvador Casani-Galdon including associated specialties, affiliations and a list of published articles.
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7
Citations
23
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Recent Articles
1.
Moore M, Wekhande S, Issner R, Collins A, Cruz A, Liu Y, et al.
Nat Commun
. 2025 Feb;
16(1):1357.
PMID: 39905017
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity...
2.
Mowery C, Freimer J, Chen Z, Casani-Galdon S, Umhoefer J, Arce M, et al.
Nat Genet
. 2024 May;
56(6):1156-1167.
PMID: 38811842
Cis-regulatory elements (CREs) interact with trans regulators to orchestrate gene expression, but how transcriptional regulation is coordinated in multi-gene loci has not been experimentally defined. We sought to characterize the...
3.
Cerda-Smith C, Hutchinson H, Liu A, Goel V, Sept C, Kim H, et al.
bioRxiv
. 2023 Oct;
PMID: 37786671
Enhancers possess both structural elements mediating promoter looping and functional elements mediating gene expression. Traditional models of enhancer-mediated gene regulation imply genomic overlap or immediate adjacency of these elements. We...
4.
Bevill S, Casani-Galdon S, El Farran C, Cytrynbaum E, Macias K, Oldeman S, et al.
Cell Genom
. 2023 Jul;
3(7):100321.
PMID: 37492096
Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2 overexpression on chromatin, gene expression, and cellular phenotypes...
5.
Pillon N, Sardon Puig L, Altintas A, Kamble P, Casani-Galdon S, Gabriel B, et al.
Life Sci Alliance
. 2022 Oct;
6(1).
PMID: 36302651
Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid overload may interact with the circadian clock and alter the...
6.
Yang C, Fagnocchi L, Apostle S, Wegert V, Casani-Galdon S, Landgraf K, et al.
Nat Metab
. 2022 Sep;
4(9):1150-1165.
PMID: 36097183
Studies in genetically 'identical' individuals indicate that as much as 50% of complex trait variation cannot be traced to genetics or to the environment. The mechanisms that generate this 'unexplained'...
7.
Casani-Galdon S, Pereira C, Conesa A
Bioinformatics
. 2020 Dec;
36(Suppl_2):i795-i803.
PMID: 33381819
Motivation: Molecular pathway databases represent cellular processes in a structured and standardized way. These databases support the community-wide utilization of pathway information in biological research and the computational analysis of...
8.
Sanchez-Gaya V, Casani-Galdon S, Ugidos M, Kuang Z, Mellor J, Conesa A, et al.
Front Genet
. 2018 Dec;
9:578.
PMID: 30555512
The Yeast Metabolic Cycle (YMC) is a model system in which levels of around 60% of the yeast transcripts cycle over time. The spatial and temporal resolution provided by the...