Sakari Simula
Overview
Explore the profile of Sakari Simula including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
25
Citations
231
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0
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Recent Articles
11.
Simula S, Laitinen T, Laitinen T, Hartikainen P, Hartikainen J
Mult Scler Relat Disord
. 2016 Dec;
10:86-89.
PMID: 27919506
Background: Fingolimod is an immunomodulator with a disease modifying effect on relapsing-remitting multiple sclerosis (RRMS). A heart rate (HR) decrease shortly after fingolimod initiation, however, requires a clinical vigilance. The...
12.
Simula S, Laitinen T, Laitinen T, Hartikainen P, Hartikainen J
Physiol Rep
. 2016 Sep;
4(17).
PMID: 27624686
Fingolimod is an oral sphingosine-1-phospate (S1P) receptor modulator for the treatment of relapsing-remitting multiple sclerosis (RRMS). In addition to therapeutic effects on lymphoid and neural tissue, fingolimod influences cardiovascular system...
13.
Simula S, Laitinen T, Laitinen T, Tarkiainen T, Hartikainen P, Hartikainen J
Mult Scler
. 2015 Sep;
22(8):1080-5.
PMID: 26362903
Background: Fingolimod modulates sphingosine-1-phosphate receptors that are also found in cardiovascular tissue. Objective: To investigate the effects of fingolimod on cardiac autonomic regulation prospectively. Methods: Twenty-seven relapsing-remitting multiple sclerosis patients...
14.
Simula S, Laitinen T, Laitinen T, Tarkiainen T, Hartikainen J, Hartikainen P
J Neuroimmune Pharmacol
. 2015 Jun;
10(4):651-4.
PMID: 26092537
Fingolimod is a novel disease-modifying drug for relapsing-remitting multiple sclerosis (RRMS). Fingolimod initiation associates with a decrease in heart rate (HR). However, the long-term effects of fingolimod on HR are...
15.
Laine H, Vuorinen S, Simula S
Duodecim
. 2014 Mar;
130(2):174-7.
PMID: 24605433
Clostridium tetani, the bacterium causing tetanus, can be found both in the soil and intestinal normal flora. While the majority of the Finnish population has adequate vaccination protection, part of...
16.
17.
Simula S, Vanninen E, Lehto S, Hedman A, Pajunen P, Syvanne M, et al.
Clin Auton Res
. 2013 Dec;
24(1):31-7.
PMID: 24343834
Purpose: Heart rate variability (HRV) becomes impaired in symptomatic coronary artery disease (CAD), particularly, after myocardial infarction. The mechanism how CAD results in impairment of cardiac autonomic regulation is not...
18.
Simula S, Muuronen A, Taina M, Jakala P, Sipola P, Vanninen R, et al.
J Stroke Cerebrovasc Dis
. 2013 Sep;
23(4):717-23.
PMID: 24045085
Background: Prolonged QT interval associates with increased risk for sudden cardiac death after acute ischemic stroke. However, pathophysiology of prolonged QT interval after stroke is poorly elucidated. In this study,...
19.
Simula S, Laitinen T, Vanninen E, Pajunen P, Syvanne M, Hedman A, et al.
Clin Physiol Funct Imaging
. 2012 Dec;
33(1):70-4.
PMID: 23216768
Background: Baroreflex sensitivity (BRS) reflects the effectiveness of cardiac parasympathetic regulation. BRS becomes impaired in stable coronary artery disease (CAD) and after myocardial infarction and carries prognostic information in these...
20.
Petrasov A, Korhonen T, Tarvainen I, Simula S
Duodecim
. 2012 Jun;
128(10):1033-5.
PMID: 22724319
Dysfunction of the hypoglossal nerve (nervus hypoglossus) occurs usually as part of a larger symptom complex, only rarely being the sole symptom of a neurologic disorder. Peripheral etiology must also...