Sachindra R Joshi
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Explore the profile of Sachindra R Joshi including associated specialties, affiliations and a list of published articles.
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11
Citations
204
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Recent Articles
1.
Joshi S, Atabay E, Liu J, Ding Y, Briscoe S, Alexander M, et al.
Front Cardiovasc Med
. 2023 Mar;
10:1064290.
PMID: 36910526
Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion protein (ActRIIA-Fc) was found previously...
2.
Joshi S, Liu J, Bloom T, Atabay E, Kuo T, Lee M, et al.
Sci Rep
. 2022 May;
12(1):7803.
PMID: 35551212
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. However,...
3.
Andre P, Joshi S, Briscoe S, Alexander M, Li G, Kumar R
Front Med (Lausanne)
. 2022 Feb;
8:814222.
PMID: 35141256
Pulmonary arterial hypertension (PAH) is a rare disease characterized by high blood pressure in the pulmonary circulation driven by pathological remodeling of distal pulmonary arteries, leading typically to death by...
4.
Hashimoto R, Lanier G, Dhagia V, Joshi S, Jordan A, Waddell I, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Jan;
318(2):L386-L401.
PMID: 31913656
Pulmonary hypertension (PH) is a multicellular and progressive disease with a high mortality rate. Among many cell types, hematopoietic stem cells (HSCs) are incriminated in the pathogenesis of PH. However,...
5.
Oshima K, Crockett E, Joshi S, McLendon J, Matsumoto Y, McMurtry I, et al.
Am J Physiol Lung Cell Mol Physiol
. 2019 Oct;
317(6):L805-L815.
PMID: 31577161
Histological observations in human pulmonary arterial hypertension (PAH) suggest a link between plexiform lesions and pulmonary supernumerary arteries. Pulmonary microvascular endothelial cells are characterized as hyperproliferative and progenitor-like. This study...
6.
Sphingosine-1-phosphate is involved in the occlusive arteriopathy of pulmonary arterial hypertension
Gairhe S, Joshi S, Bastola M, McLendon J, Oka M, Fagan K, et al.
Pulm Circ
. 2016 Sep;
6(3):369-80.
PMID: 27683614
Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine-1-phosphate (S1P) is...
7.
Kizub I, Lakhkar A, Dhagia V, Joshi S, Jiang H, Wolin M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Feb;
310(8):L772-83.
PMID: 26895643
In response to hypoxia, the pulmonary artery normally constricts to maintain optimal ventilation-perfusion matching in the lung, but chronic hypoxia leads to the development of pulmonary hypertension. The mechanisms of...
8.
Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension
McLendon J, Joshi S, Sparks J, Matar M, Fewell J, Abe K, et al.
J Control Release
. 2015 May;
210:67-75.
PMID: 25979327
Therapies that exploit RNA interference (RNAi) hold great potential for improving disease outcomes. However, there are several challenges that limit the application of RNAi therapeutics. One of the most important...
9.
Joshi S, Comer B, McLendon J, Gerthoffer W
Mol Cell Pharmacol
. 2014 Oct;
4(1):1-16.
PMID: 25309675
Advances in studies of microRNA (miRNA) expression and function in smooth muscles illustrate important effects of small noncoding RNAs on cell proliferation, hypertrophy and differentiation. An emerging theme in miRNA...
10.
Joshi S, Sarpong Y, Peterson R, Scovell W
Nucleic Acids Res
. 2012 Sep;
40(20):10161-71.
PMID: 22941653
High mobility group protein 1 (HMGB1) interacts with DNA and chromatin to influence the regulation of transcription, DNA repair and recombination. We show that HMGB1 alters the structure and stability...