Sachin A Kumar
Overview
Explore the profile of Sachin A Kumar including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
469
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Recent Articles
1.
Shahab S, Roggeveen C, Sun J, Kunhiraman H, McSwain L, Juraschka K, et al.
Mol Oncol
. 2023 Jun;
17(9):1784-1802.
PMID: 37341142
Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is...
2.
Okonechnikov K, Camgoz A, Chapman O, Wani S, Park D, Hubner J, et al.
Nat Commun
. 2023 Apr;
14(1):2300.
PMID: 37085539
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma...
3.
Hendrikse L, Haldipur P, Saulnier O, Millman J, Sjoboen A, Erickson A, et al.
Nature
. 2022 Nov;
612(7940):E12.
PMID: 36446943
No abstract available.
4.
Chen X, Momin A, Wanggou S, Wang X, Min H, Dou W, et al.
Neuron
. 2022 Nov;
111(1):30-48.e14.
PMID: 36323321
Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, and quiescent tumor cells, which resist conventional chemotherapy. Here, we show...
5.
Hendrikse L, Haldipur P, Saulnier O, Millman J, Sjoboen A, Erickson A, et al.
Nature
. 2022 Sep;
609(7929):1021-1028.
PMID: 36131014
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain. Mutations that activate Sonic hedgehog signalling lead to...
6.
Donovan L, Delaidelli A, Joseph S, Bielamowicz K, Fousek K, Holgado B, et al.
Nat Med
. 2021 May;
27(6):1117-1120.
PMID: 34045740
No abstract available.
7.
Shahzad U, Taccone M, Kumar S, Okura H, Krumholtz S, Ishida J, et al.
Neuro Oncol
. 2020 Dec;
23(5):718-731.
PMID: 33378446
For decades, cell biologists and cancer researchers have taken advantage of non-murine species to increase our understanding of the molecular processes that drive normal cell and tissue development, and when...
8.
Michealraj K, Kumar S, Kim L, Cavalli F, Przelicki D, Wojcik J, et al.
Cell
. 2020 May;
181(6):1329-1345.e24.
PMID: 32445698
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for...
9.
Donovan L, Delaidelli A, Joseph S, Bielamowicz K, Fousek K, Holgado B, et al.
Nat Med
. 2020 Apr;
26(5):720-731.
PMID: 32341580
Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas...
10.
Suzuki H, Kumar S, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, et al.
Nature
. 2019 Oct;
574(7780):707-711.
PMID: 31664194
In cancer, recurrent somatic single-nucleotide variants-which are rare in most paediatric cancers-are confined largely to protein-coding genes. Here we report highly recurrent hotspot mutations (r.3A>G) of U1 spliceosomal small nuclear...