Sachiko Shiba
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Explore the profile of Sachiko Shiba including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
185
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Recent Articles
1.
Azuma K, Ikeda K, Shiba S, Sato W, Horie K, Hasegawa T, et al.
iScience
. 2024 Feb;
27(2):108871.
PMID: 38313054
Estrogen receptor-binding fragment associated antigen 9 (EBAG9) exerts tumor-promoting effects by inducing immune escape. We focused on the physiological functions of EBAG9 by investigating the bone phenotypes of -knockout mice....
2.
Takenouchi Y, Seki Y, Shiba S, Ohtake K, Nobe K, Kasono K
BMC Endocr Disord
. 2022 Apr;
22(1):103.
PMID: 35436932
Background: Chronic hyperglycemia in diabetes causes atherosclerosis and progresses to diabetic macroangiopathy, and can lead to coronary heart disease, myocardial infarction and cerebrovascular disease. Palmitoleic acid (POA) is a product...
3.
Sonoda K, Kono Y, Kitamori K, Ohtake K, Shiba S, Kasono K, et al.
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328352
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the...
4.
Shiba S, Ikeda K, Horie-Inoue K, Azuma K, Hasegawa T, Amizuka N, et al.
Mol Cell Biol
. 2021 Feb;
41(4).
PMID: 33526452
γ-Glutamyl carboxylase (GGCX) is a vitamin K (VK)-dependent enzyme that catalyzes the γ-carboxylation of glutamic acid residues in VK-dependent proteins. The anticoagulant warfarin is known to reduce GGCX activity by...
5.
Oono K, Ohtake K, Watanabe C, Shiba S, Sekiya T, Kasono K
Lipids Health Dis
. 2020 Feb;
19(1):15.
PMID: 32005121
Background: n-3 polyunsaturated fatty acids (n-3 PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are thought to exert protective effects in cardiovascular diseases. In addition, n-3 PUFAs have demonstrated...
6.
Shiba S, Ikeda K, Suzuki T, Shintani D, Okamoto K, Horie-Inoue K, et al.
Endocrinology
. 2019 Jul;
160(8):1895-1906.
PMID: 31265065
Low-grade and early-stage endometrial cancer usually has a favorable prognosis, whereas recurrent or metastatic disease is often difficult to cure. Thus, the molecular mechanisms underlying advanced pathophysiology remain to be...
7.
Shiba S, Ikeda K, Horie-Inoue K, Nakayama A, Tanaka T, Inoue S
Sci Rep
. 2017 Aug;
7(1):7606.
PMID: 28790391
Mitochondria are essential organelles to efficiently produce ATP by ATP-synthase, which uses a proton-gradient generated by respiratory chain complexes. We previously demonstrated that COX7RP/COX7A2L/SCAF1 is a key molecule that promotes...
8.
Nagai S, Ikeda K, Horie-Inoue K, Shiba S, Nagasawa S, Takeda S, et al.
Biochem Biophys Res Commun
. 2016 Dec;
480(4):758-764.
PMID: 27983991
Estrogen is a hormone that regulates physiological processes and its dysregulation may relate to muscle disorders particularly in female, although the mechanism remains to be elucidated. We here show that...
9.
Azuma K, Shiba S, Hasegawa T, Ikeda K, Urano T, Horie-Inoue K, et al.
J Bone Miner Res
. 2015 Jan;
30(7):1245-54.
PMID: 25600070
Vitamin K is a fat-soluble vitamin that is necessary for blood coagulation. In addition, it has bone-protective effects. Vitamin K functions as a cofactor of γ-glutamyl carboxylase (GGCX), which activates...
10.
Shiba S, Ikeda K, Azuma K, Hasegawa T, Amizuka N, Horie-Inoue K, et al.
Biochem Biophys Res Commun
. 2014 Sep;
453(3):350-5.
PMID: 25264202
Vitamin K-dependent γ-glutamyl carboxylase (GGCX) is an enzyme that catalyzes the conversion of glutamic acid to gamma-carboxyglutamic acid in substrate proteins. Among GGCX target proteins, recent evidence indicates that osteocalcin...