Sachia G Khasar
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Explore the profile of Sachia G Khasar including associated specialties, affiliations and a list of published articles.
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14
Citations
438
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Recent Articles
1.
Khasar S, Dina O, Green P, Levine J
J Pain
. 2009 Jul;
10(10):1073-7.
PMID: 19576859
Unlabelled: Although stress plays an important role in chronic widespread pain syndromes, such as fibromyalgia, the underlying mechanism has remained elusive. We have recently demonstrated, in a model of chronic...
2.
Dina O, Khasar S, Alessandri-Haber N, Bogen O, Chen X, Green P, et al.
Eur J Neurosci
. 2008 Sep;
28(6):1180-90.
PMID: 18783367
The neurotoxic effects of catecholamine metabolites have been implicated in neurodegenerative diseases. As some sensory neurons express tyrosine hydroxylase and monoamine oxidase (MAO), we investigated the potential contribution of catecholamine...
3.
Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain
Khasar S, Burkham J, Dina O, Brown A, Bogen O, Alessandri-Haber N, et al.
J Neurosci
. 2008 May;
28(22):5721-30.
PMID: 18509033
Stress dramatically exacerbates pain in diseases such as fibromyalgia and rheumatoid arthritis, but the underlying mechanisms are unknown. We tested the hypothesis that stress causes generalized hyperalgesia by enhancing pronociceptive...
4.
Dina O, Khasar S, Alessandri-Haber N, Green P, Messing R, Levine J
Eur J Neurosci
. 2007 Dec;
27(1):83-92.
PMID: 18093169
Chronic alcohol consumption induces a painful small-fiber peripheral neuropathy, the severity of which increases during alcohol withdrawal. Chronic alcohol consumption also produces a sustained increase in stress hormones, epinephrine and...
5.
Summer G, Romero-Sandoval E, Bogen O, Dina O, Khasar S, Levine J
Pain
. 2007 Jun;
135(1-2):98-107.
PMID: 17590515
Thermal burns induce pain at the site of injury, mechanical hyperalgesia, associated with a complex time-dependent inflammatory response. To determine the contribution of inflammatory mediators to burn injury-induced mechanical hyperalgesia,...
6.
Levine J, Khasar S, Green P
Ann N Y Acad Sci
. 2006 Jul;
1069:155-67.
PMID: 16855143
Inflammation and inflammatory diseases are sexually dimorphic, but the underlying causes for this observed sexual dimorphism are poorly understood. We discuss neural-immune mechanisms that underlie sexual dimorphism in three critical...
7.
Khasar S, Dina O, Green P, Levine J
Eur J Neurosci
. 2005 Jul;
21(12):3379-86.
PMID: 16026475
Epinephrine produces sexually dimorphic beta(2)-adrenergic receptor-mediated mechanical hyperalgesia, with male rats exhibiting greater hyperalgesia. Because female rats have higher plasma epinephrine levels, and beta-adrenergic receptor sensitivity is affected by chronic...
8.
Khasar S, Green P, Levine J
Pain
. 2005 Jun;
116(1-2):79-86.
PMID: 15936144
While it is well established that acute stress can produce antinociception, a phenomenon referred to as stress-induced analgesia, repeated exposure to stress can have the opposite effect. Since, chronic pain...
9.
Joseph E, Chen X, Khasar S, Levine J
Pain
. 2004 Jan;
107(1-2):147-58.
PMID: 14715401
To elucidate the underlying mechanisms involved in AIDS therapy-induced peripheral neuropathy, we have developed a model of nucleoside analog reverse transcriptase inhibitor-induced painful peripheral neuropathy in the rat, using 2',3'-dideoxycytidine...
10.
Khasar S, Miao F, Gear R, Green P, Isenberg W, Levine J
J Pain
. 2003 Nov;
3(5):369-76.
PMID: 14622740
Bradykinin-induced mechanical hyperalgesia is sympathetically dependent and B(2)-type bradykinin receptor-mediated in the rat; however, a sympathetically independent component of bradykinin hyperalgesia is shown after subdiaphragmatic vagotomy. We evaluated the mechanism...