Sabrina Silva-Mendonca
Overview
Explore the profile of Sabrina Silva-Mendonca including associated specialties, affiliations and a list of published articles.
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4
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1
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Recent Articles
1.
Cyto-Safe: A Machine Learning Tool for Early Identification of Cytotoxic Compounds in Drug Discovery
Feitosa F, F Cabral V, Sanches I, Silva-Mendonca S, Borba J, Braga R, et al.
J Chem Inf Model
. 2024 Dec;
64(24):9056-9062.
PMID: 39661446
Cytotoxicity is essential in drug discovery, enabling early evaluation of toxic compounds during screenings to minimize toxicological risks. assays support high-throughput screening, allowing for efficient detection of toxic substances while...
2.
Calit J, Prajapati S, Benavente E, Araujo J, Deng B, Miura K, et al.
JACS Au
. 2024 Nov;
4(10):3942-3952.
PMID: 39483245
Malaria control and elimination efforts would benefit from the identification and validation of new malaria chemotherapeutics. Recently, a transgenic line was used to perform a series of high-throughput in vitro...
3.
Borba J, Salazar-Alvarez L, Ferreira L, Silva-Mendonca S, Silva M, Sanches I, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1386-1395.
PMID: 39140064
Malaria presents a significant challenge to global public health, with around 247 million cases estimated to occur annually worldwide. The growing resistance of parasites to existing therapies underscores the urgent...
4.
Purificacao A, Silva-Mendonca S, Cruz L, Sacramento C, Temerozo J, Fintelman-Rodrigues N, et al.
ACS Omega
. 2024 Mar;
9(10):11418-11430.
PMID: 38496952
The urgent need for effective treatments against emerging viral diseases, driven by drug-resistant strains and new viral variants, remains critical. We focus on inhibiting the human dihydroorotate dehydrogenase (DHODH), one...