Sabarinathan Ramachandran
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Explore the profile of Sabarinathan Ramachandran including associated specialties, affiliations and a list of published articles.
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46
Citations
866
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Recent Articles
1.
Leishman D, Oppler S, Stone L, OBrien T, Ramachandran S, Willenberg B, et al.
Front Transplant
. 2024 Jul;
3():1352777.
PMID: 38993753
Introduction: Successful diabetes reversal using pancreatic islet transplantation by various groups illustrates the significant achievements made in cell-based diabetes therapy. While clinically, intraportal islet delivery is almost exclusively used, it...
2.
Oppler S, Stone L, Leishman D, Janecek J, Moore M, Rangarajan P, et al.
Sci Adv
. 2024 Jan;
10(1):eadi4919.
PMID: 38181083
Cell-based therapies hold promise for many chronic conditions; however, the continued need for immunosuppression along with challenges in replacing cells to improve durability or retrieving cells for safety are major...
3.
Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells
Baik J, Ortiz-Cordero C, Magli A, Azzag K, Crist S, Yamashita A, et al.
Cells
. 2023 May;
12(8).
PMID: 37190056
Pluripotent stem (PS) cells enable the scalable production of tissue-specific derivatives with therapeutic potential for various clinical applications, including muscular dystrophies. Given the similarity to human counterparts, the non-human primate...
4.
Peng K, Carey T, Lech P, Vandergaast R, Munoz-Alia M, Packiriswamy N, et al.
Vaccine
. 2022 Mar;
40(15):2342-2351.
PMID: 35282925
An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and...
5.
Nugent J, Singh A, Wirth K, Oppler S, Hocum Stone L, Janecek J, et al.
iScience
. 2021 Dec;
24(12):103421.
PMID: 34877488
The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic...
6.
Graham M, Ramachandran S, Singh A, Moore M, Flanagan E, Azimzadeh A, et al.
Am J Transplant
. 2021 Oct;
22(3):745-760.
PMID: 34704345
A safe, efficacious, and clinically applicable immunosuppressive regimen is necessary for islet xenotransplantation to become a viable treatment option for diabetes. We performed intraportal transplants of wild-type adult porcine islets...
7.
Hocum Stone L, Oppler S, Nugent J, Gresch S, Hering B, Murtaugh M, et al.
Sci Rep
. 2021 Jan;
11(1):2340.
PMID: 33504894
Cytokine profiling is a valuable tool for monitoring immune responses associated with disease and treatment. This study assessed the impact of sex and sedation on serum cytokines in healthy nonhuman...
8.
Safley S, Graham M, Weegman B, Einstein S, Barber G, Janecek J, et al.
Transplantation
. 2019 Aug;
104(2):259-269.
PMID: 31385927
Background: We have utilized a noninvasive technique for measuring the partial pressure of oxygen (pO2) in alginate microcapsules implanted intraperitoneally in healthy nonhuman primates (NHPs). Average pO2 is important for...
9.
Singh A, Ramachandran S, Graham M, Daneshmandi S, Heller D, Suarez-Pinzon W, et al.
Nat Commun
. 2019 Aug;
10(1):3495.
PMID: 31375697
Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts in murine studies. Here...
10.
Xiao X, Guo P, Shiota C, Zhang T, Coudriet G, Fischbach S, et al.
Cell Stem Cell
. 2018 Jan;
22(1):78-90.e4.
PMID: 29304344
Successful strategies for treating type 1 diabetes need to restore the function of pancreatic beta cells that are destroyed by the immune system and overcome further destruction of insulin-producing cells....