S T Holgate
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Explore the profile of S T Holgate including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Holgate S, Noonan M, Chanez P, Busse W, Dupont L, Pavord I, et al.
Eur Respir J
. 2010 Nov;
37(6):1352-9.
PMID: 21109557
Increased tumour necrosis factor-α levels have been observed in bronchial biopsies and induced sputum from subjects with severe asthma. We investigated etanercept (ETN) as a therapeutic option for treating moderate-to-severe...
12.
Papadopoulos N, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, et al.
Allergy
. 2010 Nov;
66(4):458-68.
PMID: 21087215
A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible...
13.
Morjaria J, Babu K, Vijayanand P, Chauhan A, Davies D, Holgate S
Thorax
. 2010 Oct;
66(6):537.
PMID: 20880874
No abstract available.
14.
Church M, Maurer M, Simons F, Bindslev-Jensen C, Van Cauwenberge P, Bousquet J, et al.
Allergy
. 2010 Feb;
65(4):459-66.
PMID: 20146728
Background: First-generation H(1)-antihistamines obtained without prescription are the most frequent form of self-medication for allergic diseases, coughs and colds and insomnia even though they have potentially dangerous unwanted effects which...
15.
Massanari M, Holgate S, Busse W, Jimenez P, Kianifard F, Zeldin R
Respir Med
. 2009 Oct;
104(2):188-96.
PMID: 19846286
Eosinophilia is an established marker of asthma-related inflammation. We assessed the effect of omalizumab on peripheral blood eosinophil counts using a pooled analysis of data from five randomized, double-blind, placebo-controlled...
16.
Yang I, Fong K, Zimmerman P, Holgate S, Holloway J
Postgrad Med J
. 2009 Jul;
85(1006):428-36.
PMID: 19633009
There is large variation between individuals in their response to air pollutants. This review summarises the existing evidence that genetic factors influence the mechanisms of lung injury caused by air...
17.
Self J, Haitchi H, Griffiths H, Holgate S, Davies D, Lotery A
Eye (Lond)
. 2009 Mar;
24(1):165-9.
PMID: 19265863
Aims: Mutations in the FERM domain containing 7 (FRMD7) genes are known to cause a significant number of cases of congenital idiopathic nystagmus (CIN). Only limited expression data exist suggesting...
18.
Haitchi H, Yoshisue H, Ribbene A, Wilson S, Holloway J, Bucchieri F, et al.
Eur Respir J
. 2009 Feb;
33(5):1095-104.
PMID: 19213785
Ciliated Bronchial Epithelium (CBE) 1 is a novel gene, which is expressed in ciliated cells. As cilia are important during embryogenesis, the present authors characterised the murine homologue of CBE1...
19.
Konstantinidis A, Puddicombe S, Mochizuki A, Sheth P, Yang I, Yoshisue H, et al.
J Investig Allergol Clin Immunol
. 2008 Jun;
18(3):174-80.
PMID: 18564628
Background: Interleukin (IL) 13 is a key cytokine in asthma, regulating fibrosis, airway remodeling, induction of immunoglobulin E synthesis by B cells, bronchial hyperresponsiveness, and mucus production. IL-13 signals through...
20.
Holloway J, Barton S, Holgate S, Rose-Zerilli M, Sayers I
Allergy
. 2008 Jun;
63(8):1046-53.
PMID: 18547289
Background: Leukotrienes (LTs) have been identified as central mediators in asthma and allergy. Pharmacological inhibition of cysteinyl-LT activity improves asthma symptoms and control. Accumulating evidence suggests a role for the...