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S Sachetelli

Explore the profile of S Sachetelli including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 252
Followers 0
Related Specialties
Biochemistry
Biophysics
Nephrology
Top 10 Co-Authors
J Lagace
C Beaulac
D-F Guo
J R Ingelfinger
S-L Zhang
M-L Brezniceanu
J G Filep
J S D Chan
F Liu
S Tran
Published In
Biochim Biophys Acta
Kidney Int
J Antimicrob Chemother
J Drug Target
Affiliations
Soon will be listed here.
Recent Articles
1.
Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice
Brezniceanu M, Liu F, Wei C, Tran S, Sachetelli S, Zhang S, et al.
Kidney Int . 2007 Mar; 71(9):912-23. PMID: 17342175
Increased generation of reactive oxygen species (ROS) leads to oxidative stress in diabetes. Catalase is a highly conserved heme-containing protein that reduces hydrogen peroxide to water and oxygen and is...
2.
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney
Sachetelli S, Liu Q, Zhang S, Liu F, Hsieh T, Brezniceanu M, et al.
Kidney Int . 2006 Mar; 69(6):1016-23. PMID: 16528251
Angiotensinogen (ANG) is the sole substrate of the renin-angiotensin system (RAS). Clinical studies have shown that RAS activation may lead to hypertension, a major cardiovascular and renal risk factor. To...
3.
Demonstration of a fusion mechanism between a fluid bactericidal liposomal formulation and bacterial cells
Sachetelli S, Khalil H, Chen T, Beaulac C, Senechal S, Lagace J
Biochim Biophys Acta . 2000 Feb; 1463(2):254-66. PMID: 10675504
It was previously demonstrated that fluid liposomal-encapsulated tobramycin, named Fluidosomes, was successful in eradicating mucoid Pseudomonas aeruginosa in an animal model of chronic pulmonary infection, whereas free antibiotic did not...
4.
Aerosolization of low phase transition temperature liposomal tobramycin as a dry powder in an animal model of chronic pulmonary infection caused by Pseudomonas aeruginosa
Beaulac C, Sachetelli S, Lagace J
J Drug Target . 1999 Dec; 7(1):33-41. PMID: 10614813
Eradication of mucoid Pseudomonas aeruginosa in an animal model of chronic pulmonary infection has been previously demonstrated following the intratracheal administration of Fluidosomes, a low phase transition temperature (low T(C))...
5.
Evaluation of the pulmonary and systemic immunogenicity of Fluidosomes, a fluid liposomal-tobramycin formulation for the treatment of chronic infections in lungs
Sachetelli S, Beaulac C, Riffon R, Lagace J
Biochim Biophys Acta . 1999 Aug; 1428(2-3):334-40. PMID: 10434052
In previous studies, we have developed a fluid bactericidal liposomal formulation containing tobramycin, called Fluidosomes, which has been shown to be highly bactericidal both in in vitro and in in...
6.
In-vitro bactericidal efficacy of sub-MIC concentrations of liposome-encapsulated antibiotic against gram-negative and gram-positive bacteria
Beaulac C, Sachetelli S, Lagace J
J Antimicrob Chemother . 1998 Mar; 41(1):35-41. PMID: 9511035
It has been shown previously that tobramycin encapsulated in fluid liposomes (composed of dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylglycerol (DMPG)) eradicated mucoid Pseudomonas aeruginosa in an animal model of chronic pulmonary infection....
7.
Aminoglycoside detection using a universal ELISA binding procedure onto polystyrene microtiter plates in comparison with HPLC analysis and microbiological agar-diffusion assay
Sachetelli S, Beaulac C, Lagace J
Biochim Biophys Acta . 1998 Feb; 1379(1):35-41. PMID: 9468330
The use of enzyme-linked immunosorbent assay for the detection of aminoglycosides has been hindered due to low molecular weight compound adsorption to solid phases. Here, we describe an enzyme-linked immunosorbent...