S P Cobbold
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Explore the profile of S P Cobbold including associated specialties, affiliations and a list of published articles.
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76
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1808
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Recent Articles
1.
Regateiro F, Cobbold S, Waldmann H
Clin Exp Immunol
. 2012 Dec;
171(1):1-7.
PMID: 23199317
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Conversely, the ATP metabolite adenosine is mainly an anti-inflammatory molecule. The ecto-enzymes CD39 and CD73 can dephosphorylate extracellular...
2.
Agorogiannis E, Regateiro F, Howie D, Waldmann H, Cobbold S
Am J Transplant
. 2012 Mar;
12(4):835-45.
PMID: 22390151
IL-17A-producing helper T (Th17) cells have been implicated in the pathogenesis of autoimmune disease, inflammatory bowel disease and graft rejection, however the mechanisms by which they cause tissue damage remain...
3.
Li Z, Benghiat F, Charbonnier L, Kubjak C, Rivas M, Cobbold S, et al.
Am J Transplant
. 2008 Oct;
8(12):2527-36.
PMID: 18853957
The growing development of composite tissue allografts (CTA) highlights the need for tolerance induction protocols. Herein, we developed a mouse model of heterotopic limb allograft in a stringent strain combination...
4.
Daley S, Cobbold S, Waldmann H
Am J Transplant
. 2008 Sep;
8(11):2265-71.
PMID: 18782294
CD40L antibodies have proven to be powerful immunosuppressive agents in nonhuman primates but unfortunately perturb blood coagulation. Neither the therapeutic nor the prothrombotic mechanism of anti-CD40L is defined sufficiently to...
5.
Cobbold S
J Nephrol
. 2008 Jul;
21(4):485-96.
PMID: 18651537
Rodent models of transplantation have demonstrated that it is possible to induce specific immunological tolerance of donor antigens and indefinite graft survival in the absence of any continued immunosuppression. If...
6.
Zelenika D, Adams E, Humm S, Lin C, Waldmann H, Cobbold S
Immunol Rev
. 2001 Nov;
182:164-79.
PMID: 11722632
Peripheral tolerance to allogeneic organ grafts can be induced in rodents by treating with non-depleting CD4 and CD8 monoclonal antibodies. This tolerance is maintained by CD4+ T cells with a...
7.
Waldmann H, Cobbold S, Fairchild P, Adams E
Curr Opin Pharmacol
. 2001 Nov;
1(4):392-7.
PMID: 11710738
The immune system is naturally unresponsive to 'self' antigens. Improved knowledge of mechanisms underlying self tolerance is giving rise to a new generation of immunosuppressive agents, that can exploit these...
8.
Graca L, Honey K, Adams E, Cobbold S, Waldmann H
J Immunol
. 2000 Oct;
165(9):4783-6.
PMID: 11045999
Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag...
9.
Honey K, Cobbold S, Waldmann H
Transplantation
. 2000 Jun;
69(8):1683-9.
PMID: 10836381
Background: Nonlytic anti-CD4 monoclonal antibody therapy can be used to induce transplantation tolerance in rodent models. Such tolerance is often associated with dominant regulation, mediated by CD4+ cells, and characterized...
10.
Honey K, Bemelman F, Cobbold S, Waldmann H
Transplantation
. 2000 Jun;
69(8):1676-82.
PMID: 10836380
Background: Monoclonal antibody induced tolerance to high doses of multiple lymphocyte stimulating (MLS)+minor mismatched bone marrow has recently been associated with clonal deletion, as reported in fully allogeneic models of...