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S Dovero

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Citations 358
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Recent Articles
1.
Bourdenx M, Nioche A, Dovero S, Arotcarena M, Camus S, Porras G, et al.
Sci Adv . 2020 May; 6(20):eaaz9165. PMID: 32426502
Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established characteristic of Parkinson's disease (PD). Much evidence, accumulated from multiple experimental models,...
2.
Chansel-Debordeaux L, Bourdenx M, Dovero S, Grouthier V, Dutheil N, Espana A, et al.
Gene Ther . 2017 Aug; 24(12):801-809. PMID: 28853717
Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However, technical difficulties associated with classical transgenesis approaches in rodent...
3.
Rotge J, Aouizerate B, Amestoy V, Lambrecq V, Langbour N, Nguyen T, et al.
Transl Psychiatry . 2012 Sep; 2:e161. PMID: 23010765
Obsessive-compulsive disorder (OCD) is a frequent psychiatric disorder characterized by repetitive intrusive thoughts and severe anxiety, leading to compulsive behaviors. Although medical treatment is effective in most cases, resistance is...
4.
Bezard E, Dovero S, Prunier C, Ravenscroft P, Chalon S, Guilloteau D, et al.
J Neurosci . 2001 Aug; 21(17):6853-61. PMID: 11517273
The concept of a threshold of dopamine (DA) depletion for onset of Parkinson's disease symptoms, although widely accepted, has, to date, not been determined experimentally in nonhuman primates in which...
5.
Baufreton J, Garret M, Dovero S, Dufy B, Bioulac B, Taupignon A
J Neurophysiol . 2001 Jun; 86(1):75-85. PMID: 11431489
The subthalamic nucleus (STN) influences the output of the basal ganglia, thereby interfering with motor behavior. The main inputs to the STN are GABAergic. We characterized the GABA(A) receptors expressed...
6.
Bezard E, Dovero S, Imbert C, Boraud T, Gross C
Synapse . 2000 Oct; 38(3):363-8. PMID: 11020240
The present study sought to determine whether severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication elicits spontaneous long-term compensatory sprouting in mice. Animals, once treated, were kept without further treatment for 0.5, 1, 5,...
7.
Guehl D, Bezard E, Dovero S, Boraud T, Bioulac B, Gross C
Eur J Neurol . 1999 Aug; 6(5):609-11. PMID: 10457397
This report describes the case of a 47-year-old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were...
8.
Bezard E, Gross C, Fournier M, Dovero S, Bloch B, Jaber M
Exp Neurol . 1999 Mar; 155(2):268-73. PMID: 10072302
MPTP has been shown to induce parkinsonism both in human and in nonhuman primates. The precise mechanism of dopaminergic cell death induced following MPTP treatment is still subject to intense...
9.
Bezard E, Dovero S, Bioulac B, Gross C
Exp Neurol . 1997 Dec; 148(1):288-92. PMID: 9398471
Although a valuable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of human Parkinson's disease has been developed, our knowledge of the course of nigral degeneration remains fragmentary. Experimental factors which could possibly influence...
10.
Bezard E, Dovero S, Bioulac B, Gross C
Neurosci Lett . 1997 Nov; 234(1):47-50. PMID: 9347943
The chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model we have developed in monkey reproduces all the cardinal features of Parkinson's disease, and, in particular the characteristic slow evolution of clinical signs. We still...