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S DAtri

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Recent Articles
1.
Bonmassar L, Marchesi F, Pascale E, Franzese O, Margison G, Bianchi A, et al.
Curr Med Chem . 2013 Mar; 20(19):2389-401. PMID: 23521681
Acute myeloid leukemia (AML) is a highly lethal disease, especially in old patients. Chemoresistance and the absence of host immune responses against autochthonous malignancy play a major role in the...
2.
Ruffini F, Failla C, Orecchia A, Bani M, Dorio A, Fortes C, et al.
Br J Dermatol . 2011 Jan; 164(5):1061-70. PMID: 21198538
Background: Vascular endothelial growth factor (VEGF)-A, placenta growth factor (PlGF) and their corresponding membrane receptors are involved in autocrine and paracrine regulation of melanoma growth and metastasis. Besides the membrane...
3.
Yang J, Parsons J, Nicolay N, Caporali S, Harrington C, Singh R, et al.
Oncogene . 2009 Oct; 29(3):463-8. PMID: 19838217
A significant proportion of human cancers overexpress DNA polymerase beta (Pol beta), the major DNA polymerase involved in base excision repair. The underlying mechanism and biological consequences of overexpression of...
4.
Sini M, Manca A, Cossu A, Budroni M, Botti G, Ascierto P, et al.
Br J Dermatol . 2007 Nov; 158(2):243-50. PMID: 18028495
Background: The chromosome 9p21 and its CDKN locus, with the p16 tumour suppressor gene (CDKN2A), are recognized as the genomic regions involved in the pathogenesis of melanoma. Objectives: To elucidate...
5.
Turriziani M, Caporaso P, Bonmassar L, Buccisano F, Amadori S, Venditti A, et al.
Pharmacol Res . 2006 Jan; 53(4):317-23. PMID: 16412662
Anti-tumour activity of triazene compounds of clinical interest [i.e. dacarbazine and temozolomide (TMZ)] relies mainly on the generation of methyl adducts to purine bases of DNA. Two DNA repair enzyme...
6.
Tricarico M, Nunziata C, Atzori F, Concolino F, Macchini V, DAtri S, et al.
J Exp Clin Cancer Res . 2005 Mar; 23(4):573-8. PMID: 15743026
A pilot study was conducted to assess the tolerability and the effect on host immunity of a post-surgery adjuvant treatment of melanoma patients with an anti-angiogenic agent, Tamoxifen (TAM, 20...
7.
Bonmassar L, Massara M, Cottarelli A, Aquino A, Formica V, Prete S, et al.
J Chemother . 2004 Nov; 16(5):479-86. PMID: 15565916
Preclinical studies based on a "simulation design", were performed with cultured melanoma cells prelabeled with 51Cr, added to normal blood and subjected to separation and recognition steps. Mononuclear cells (MNC)...
8.
Pagani E, Pepponi R, Fuggetta M, Prete S, Turriziani M, Bonmassar L, et al.
J Chemother . 2003 Jun; 15(2):173-83. PMID: 12797396
O6-alkylguanine-DNA alkyltransferase (OGAT) and the mismatch repair system (MRS) play a crucial role in the susceptibility of tumor cells to the cytotoxic effects of agents that generate O6-methylguanine in DNA,...
9.
Marra G, DAtri S, Yan H, Perrera C, Cannavo E, Vogelstein B, et al.
Cancer Res . 2001 Nov; 61(21):7719-21. PMID: 11691782
Conversion of diploidy to haploidy is a method that allows the generation of stable murine/human hybrid cell lines carrying selected human chromosomes in only a single copy. In this setting,...
10.
Pepponi R, Graziani G, Falcinelli S, Vernole P, Levati L, Lacal P, et al.
Carcinogenesis . 2001 Jul; 22(8):1131-7. PMID: 11470740
Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O(6)-guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin and etoposide. Recently, it has been demonstrated that...