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S Cogoi

Explore the profile of S Cogoi including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 87
Followers 0
Related Specialties
Biochemistry
Science
Pharmacology
Top 10 Co-Authors
L E Xodo
V Rapozzi
F Quadrifoglio
G van der Marel
L Xodo
C Suraci
S Diviacco
R Calligaris
P A WEINHOLD
I Apezteguia
Published In
Biochemistry
Proc Natl Acad Sci U S A
Hepatology
Curr Pharm Des
Antisense Nucleic Acid Drug Dev
Affiliations
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Recent Articles
1.
Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells
Cogoi S, Jakobsen U, Pedersen E, Vogel S, Xodo L
Sci Rep . 2016 Dec; 6:38468. PMID: 27929127
KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target for anticancer drugs. In this study we...
2.
Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide
Cogoi S, Codognotto A, Rapozzi V, Meeuwenoord N, van der Marel G, Xodo L
Biochemistry . 2005 Aug; 44(31):10510-9. PMID: 16060660
Mutations in the Kirsten ras (KRAS) gene are present in almost all pancreatic adenocarcinomas, and one common mutation is at codon 12: GGT (Gly) is transformed into GAT (Asp). In...
3.
Anti-gene strategies to down-regulate gene expression in mammalian cells
Xodo L, Cogoi S, Rapozzi V
Curr Pharm Des . 2004 Mar; 10(7):805-19. PMID: 15032705
A current goal in molecular medicine is the development of new strategies for the selective inhibition of cancer-critical genes. Triplex-forming oligonucleotides and peptide nucleic acids bind to the double helix...
4.
Anti-gene effect in live cells of AG motif triplex-forming oligonucleotides containing an increasing number of phosphorothioate linkages
Cogoi S, Rapozzi V, Quadrifoglio F, Xodo L
Biochemistry . 2001 Feb; 40(5):1135-43. PMID: 11170438
The murine Ki-ras promoter contains a unique polypurine--polypyrimidine [poly(R.Y)] sequence between -290 and -320 from the 3' boundary of exon phi. Previously we demonstrated triplex formation and transcription inhibition promoted...
5.
Downregulation of c-Ki-ras promoter activity by triplex-forming oligonucleotides endogenously generated in human 293 cells
Cogoi S, Suraci C, Del Terra E, Diviacco S, van der Marel G, van Boom J, et al.
Antisense Nucleic Acid Drug Dev . 2000 Sep; 10(4):283-95. PMID: 10984122
Exogenous triplex-forming oligodeoxynucleotides (TFO) have the capacity to modulate in vivo the expression of individual genes. As the administration of TFO to cells is not without problems, we analyzed the...
6.
Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin-treated rat
Carrella M, Feldman D, Cogoi S, Csillaghy A, WEINHOLD P
Hepatology . 1999 May; 29(6):1825-32. PMID: 10347126
An increase of biliary lipid secretion is known to occur in the rat under sustained administration of statin-type 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase inhibitors. The present study has addressed...
7.
Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor
Calligaris R, Bottardi S, Cogoi S, Apezteguia I, Santoro C
Proc Natl Acad Sci U S A . 1995 Dec; 92(25):11598-602. PMID: 8524811
GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein...