S Chul Kwon
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Explore the profile of S Chul Kwon including associated specialties, affiliations and a list of published articles.
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13
Citations
1492
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Recent Articles
1.
Wang P, Mak V, Rao L, Wu Q, Zhou Y, Sharma R, et al.
Nat Commun
. 2025 Feb;
16(1):2042.
PMID: 40016211
p85β is a regulatory subunit of the phosphoinositide 3-kinase (PI3K). Emerging evidence suggests that p85β goes beyond its role in the PI3K and is functional in the nucleus. In this...
2.
Cheng E, Lam J, Kwon S
EMBO Rep
. 2025 Feb;
PMID: 40011676
Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) technologies have evolved rapidly over the past decade with the continuous discovery of new Cas systems. In particular, RNA-targeting CRISPR-Cas13 proteins are...
3.
Kim H, Jang B, Lee D, Kwon S, Lee H
J Control Release
. 2022 Aug;
349:983-991.
PMID: 35931211
Self-assembled nucleic acid nanostructures have been widely explored for gene therapy applications due to their unique advantages. Their roles are not limited to offer intracellular delivery platforms but additionally provide...
4.
FAX-RIC enables robust profiling of dynamic RNP complex formation in multicellular organisms in vivo
Na Y, Kim H, Choi Y, Shin S, Jung J, Kwon S, et al.
Nucleic Acids Res
. 2020 Dec;
49(5):e28.
PMID: 33332543
RNA-protein interaction is central to post-transcriptional gene regulation. Identification of RNA-binding proteins relies mainly on UV-induced crosslinking (UVX) followed by the enrichment of RNA-protein conjugates and LC-MS/MS analysis. However, UVX...
5.
Kwon S, Jang H, Shen S, Baek S, Kim K, Yang J, et al.
Nucleic Acids Res
. 2020 Oct;
48(19):11097-11112.
PMID: 33035348
The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of RNase III DROSHA and dsRNA-binding DGCR8. Here, we identify Enhancer...
6.
Bae J, Kwon S, Na Y, Kim V, Kim J
Nat Struct Mol Biol
. 2020 Jun;
27(7):678-682.
PMID: 32514175
RNA-binding sites (RBSs) can be identified by liquid chromatography and tandem mass spectrometry analyses of the protein-RNA conjugates created by crosslinking, but RBS mapping remains highly challenging due to the...
7.
Kwon S, Baek S, Choi Y, Yang J, Lee Y, Woo J, et al.
Mol Cell
. 2018 Dec;
73(3):505-518.e5.
PMID: 30554947
Microprocessor, composed of DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) biogenesis by processing the primary transcripts of miRNA (pri-miRNAs). Here we investigate the mechanism by which Microprocessor selects the...
8.
Kwon S, Nguyen T, Choi Y, Jo M, Hohng S, Kim V, et al.
Cell
. 2016 Jan;
164(1-2):81-90.
PMID: 26748718
MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor....
9.
Kampmann M, Horlbeck M, Chen Y, Tsai J, Bassik M, Gilbert L, et al.
Proc Natl Acad Sci U S A
. 2015 Jun;
112(26):E3384-91.
PMID: 26080438
Genetic screening based on loss-of-function phenotypes is a powerful discovery tool in biology. Although the recent development of clustered regularly interspaced short palindromic repeats (CRISPR)-based screening approaches in mammalian cell...
10.
Nguyen T, Jo M, Choi Y, Park J, Kwon S, Hohng S, et al.
Cell
. 2015 Jun;
161(6):1374-87.
PMID: 26027739
MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs. To understand how Microprocessor recognizes...