S Brian Andrews
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Explore the profile of S Brian Andrews including associated specialties, affiliations and a list of published articles.
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17
Citations
657
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Recent Articles
1.
Trachtenberg S, Schuck P, Phillips T, Andrews S, Leapman R
PLoS One
. 2014 Mar;
9(2):e87921.
PMID: 24586297
Spiroplasma melliferum is a wall-less bacterium with dynamic helical geometry. This organism is geometrically well defined and internally well ordered, and has an exceedingly small genome. Individual cells are chemotactic,...
2.
Pivovarova N, Andrews S
J Vis Exp
. 2013 Dec;
(81):e50807.
PMID: 24300079
In this article the tools, techniques, and instruments appropriate for quantitative measurements of intracellular elemental content using the technique known as electron probe microanalysis (EPMA) are described. Intramitochondrial calcium is...
3.
Pivovarova N, Stanika R, Kazanina G, Villanueva I, Andrews S
J Neurochem
. 2013 Oct;
128(4):592-602.
PMID: 24127746
Zinc has been implicated in neurodegeneration following ischemia. In analogy with calcium, zinc has been proposed to induce toxicity via mitochondrial dysfunction, but the relative role of each cation in...
4.
Stanika R, Villanueva I, Kazanina G, Andrews S, Pivovarova N
J Neurosci
. 2012 May;
32(19):6642-50.
PMID: 22573686
Glutamate excitotoxicity, a major component of many neurodegenerative disorders, is characterized by excessive calcium influx selectively through NMDARs. However, there is a substantial uncertainty concerning why other known routes of...
5.
Machado-Vieira R, Pivovarova N, Stanika R, Yuan P, Wang Y, Zhou R, et al.
Biol Psychiatry
. 2010 Dec;
69(4):344-52.
PMID: 21167476
Background: Bipolar disorder (BPD) is characterized by altered intracellular calcium (Ca(2+)) homeostasis. Underlying mechanisms involve dysfunctions in endoplasmic reticulum (ER) and mitochondrial Ca(2+) handling, potentially mediated by B-cell lymphoma 2...
6.
Pivovarova N, Andrews S
FEBS J
. 2010 Jul;
277(18):3622-36.
PMID: 20659161
Calcium is an extraordinarily versatile signaling ion, encoding cellular responses to a wide variety of external stimuli. In neurons, mitochondria can accumulate enormous amounts of calcium, with the consequence that...
7.
Stanika R, Winters C, Pivovarova N, Andrews S
Neurobiol Dis
. 2009 Nov;
37(2):403-11.
PMID: 19879359
Hippocampal CA1 pyramidal neurons are selectively vulnerable to ischemia, while adjacent CA3 neurons are relatively resistant. Although glutamate receptor-mediated mitochondrial Ca(2+) overload and dysfunction is a major component of ischemia-induced...
8.
Stanika R, Pivovarova N, Brantner C, Watts C, Winters C, Andrews S
Proc Natl Acad Sci U S A
. 2009 Jun;
106(24):9854-9.
PMID: 19482936
Overactivation of NMDA receptors (NMDARs) is a critical early step in glutamate-evoked excitotoxic injury of CNS neurons. Distinct NMDAR-coupled pathways specified by, for example, receptor location or subunit composition seem...
9.
Trachtenberg S, Dorward L, Speransky V, Jaffe H, Andrews S, Leapman R
J Mol Biol
. 2008 Apr;
378(4):778-89.
PMID: 18400234
Spiroplasma melliferum is a wall-less bacterium with dynamic helical symmetry. Taking advantage of the simplicity of this primitive lifeform, we have used structural (electron tomography and freeze fracture of whole...
10.
Pivovarova N, Stanika R, Watts C, Brantner C, Smith C, Andrews S
J Neurochem
. 2007 Nov;
104(6):1686-99.
PMID: 18036152
In central neurons, over-stimulation of NMDA receptors leads to excessive mitochondrial calcium accumulation and damage, which is a critical step in excitotoxic death. This raises the possibility that low susceptibility...