S Afione
Overview
Explore the profile of S Afione including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
384
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Recent Articles
1.
Gao R, Yan X, Zheng C, Goldsmith C, Afione S, Hai B, et al.
Gene Ther
. 2010 Oct;
18(1):38-42.
PMID: 20882054
Previously (Shan et al, 2005), we reported that adenoviral vector-mediated transfer of the human aquaporin-1 (hAQP1) cDNA to minipig parotid glands following irradiation (IR) transiently restored salivary flow to near...
2.
Zheng C, Voutetakis A, Metzger M, Afione S, Cotrim A, Eckhaus M, et al.
Oral Dis
. 2010 Apr;
16(3):269-77.
PMID: 20374510
Objectives: Salivary glands are useful target organs for local and systemic gene therapeutics. For such applications, the regulation of transgene expression is important. Previous studies by us in murine submandibular...
3.
Voutetakis A, Zheng C, Cotrim A, Mineshiba F, Afione S, Roescher N, et al.
Gene Ther
. 2009 Sep;
17(1):50-60.
PMID: 19759566
Salivary glands are potentially useful target sites for multiple clinical applications of gene transfer. Previously, we have shown that serotype 2 adeno-associated viral (AAV2) vectors lead to stable gene transfer...
4.
Pisera D, Debeljuk L, Seilicovich A, Afione S, Duvilanski B, Diaz M, et al.
J Neuroendocrinol
. 2009 Feb;
3(3):279-83.
PMID: 19215465
Abstract The possible role of neurokinin A (NKA) in the control of prolactin secretion was studied in vivo, by injecting anti-NKA serum to ovariectomized rats treated with estrogens and to...
5.
Lasaga M, Duvilanski B, Seilicovich A, Afione S, del C Diaz M, Pisera D, et al.
J Neuroendocrinol
. 2009 Feb;
3(1):75-8.
PMID: 19215450
Abstract The effects of chronic administration of sex steroids on the content of vasoactive intestinal peptide (VIP) in the mediobasal hypothalamus and anterior pituitary were studied in adult rats. Gonadectomy...
6.
Voutetakis A, Zheng C, Wang J, Goldsmith C, Afione S, Chiorini J, et al.
Hum Gene Ther
. 2007 Oct;
18(11):1109-18.
PMID: 17939749
Salivary glands (SGs) have proven useful targets for clinical applications of gene therapeutics. In this toxicology and biodistribution study, which conforms to U.S. Food and Drug Administration Good Laboratory Practice...
7.
Katano H, Kok M, Cotrim A, Yamano S, Schmidt M, Afione S, et al.
Gene Ther
. 2005 Dec;
13(7):594-601.
PMID: 16341060
We previously demonstrated that recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in salivary gland cells in vitro and in vivo. However, it is not...
8.
Lodde B, Mineshiba F, Wang J, Cotrim A, Afione S, Tak P, et al.
Ann Rheum Dis
. 2005 Jun;
65(2):195-200.
PMID: 15975969
Background: Sjögren's syndrome (SS), an autoimmune exocrinopathy mainly affecting lachrymal and salivary glands, results in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown;...
9.
Flotte T, Agarwal A, Wang J, Song S, Fenjves E, Inverardi L, et al.
Diabetes
. 2001 Mar;
50(3):515-20.
PMID: 11246870
The ability to transfer immunoregulatory, cytoprotective, or antiapoptotic genes into pancreatic islet cells may allow enhanced posttransplantation survival of islet allografts and inhibition of recurrent autoimmune destruction of these cells...
10.
Schmidt M, Afione S, Kotin R
J Virol
. 2000 Sep;
74(20):9441-50.
PMID: 11000213
Adeno-associated virus (AAV) type 2 Rep78 is a multifunctional protein required for AAV DNA replication, integration, and gene regulation. The biochemical activities of Rep78 have been described, but the effects...