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Ryosuke Shimizu

Explore the profile of Ryosuke Shimizu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 69
Citations 425
Followers 0
Related Specialties
Biophysics
Pharmacology
Ophthalmology
Top 10 Co-Authors
Rui-Bo Jin
Ryuji Kubota
Masahide Sasaki
Mikio Fujiwara
Keiichi Edamatsu
Takashi Masuda
Kazuki Hotta
Masahiro Takeoka
Takuhiro Sonoyama
Yumiko Matsuo
Published In
Opt Express
Sci Rep
Phys Rev Lett
Infect Dis Ther
Angew Chem Int Ed Engl
Affiliations
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Recent Articles
11.
A Phase 1 Study of Ensitrelvir Fumaric Acid Tablets Evaluating the Safety, Pharmacokinetics and Food Effect in Healthy Adult Populations
Shimizu R, Sonoyama T, Fukuhara T, Kuwata A, Matsuo Y, Kubota R
Clin Drug Investig . 2023 Oct; 43(10):785-797. PMID: 37798608
Background: A reported clinical pharmacokinetics and safety study of suspension formulation of ensitrelvir, a therapeutic agent used in severe acute respiratory syndrome coronavirus 2 infection, demonstrated favorable pharmacokinetics and was...
12.
Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor
Watari R, Sawada H, Hashimoto H, Kasai Y, Oka R, Shimizu R, et al.
J Pharm Sci . 2023 Sep; 113(3):798-805. PMID: 37742997
Coproporphyrin-I (CP-I) has been investigated as an endogenous biomarker of organic anion transporting polypeptide (OATP) 1B. Here, we determined the CP-I concentrations in a cocktail drug-drug interaction (DDI) study of...
13.
A free-standing lithium phosphorus oxynitride thin film electrolyte promotes uniformly dense lithium metal deposition with no external pressure
Cheng D, Wynn T, Lu B, Marple M, Han B, Shimizu R, et al.
Nat Nanotechnol . 2023 Aug; 18(12):1448-1455. PMID: 37537275
Lithium phosphorus oxynitride (LiPON) is an amorphous solid electrolyte that has been extensively studied over the last three decades. Despite the promise of pairing it with various electrode materials, LiPON's...
14.
Pharmacokinetics, safety, and tolerability of single and multiple doses of zuranolone in Japanese and White healthy subjects: A phase 1 clinical trial
Sonoyama T, Shimizu R, Kubota R, Matsuo Y, Okutsu D, Yamanaka H, et al.
Neuropsychopharmacol Rep . 2023 Jun; 43(3):346-358. PMID: 37366077
Aim: This phase 1 study assessed the pharmacokinetics, safety, and tolerability of zuranolone in Japanese and White healthy adults, and Japanese healthy elderly subjects. Methods: This single-center study consisted of...
15.
Efficacy and safety of zuranolone in Japanese adults with major depressive disorder: A double-blind, randomized, placebo-controlled, phase 2 clinical trial
Kato M, Nakagome K, Baba T, Sonoyama T, Okutsu D, Yamanaka H, et al.
Psychiatry Clin Neurosci . 2023 May; 77(9):497-509. PMID: 37252829
Aim: To evaluate the efficacy and safety of an oral, once-daily, 14-day treatment course of zuranolone in Japanese patients with major depressive disorder (MDD). Methods: This multicenter, randomized, double-blind, placebo-controlled...
16.
Evaluation of the Drug-Drug Interaction Potential of Ensitrelvir Fumaric Acid with Cytochrome P450 3A Substrates in Healthy Japanese Adults
Shimizu R, Sonoyama T, Fukuhara T, Kuwata A, Matsuzaki T, Matsuo Y, et al.
Clin Drug Investig . 2023 May; 43(5):335-346. PMID: 37171749
Background: Management of drug-drug interactions (DDIs) for ensitrelvir, a novel 3-chymotrypsin-like protease inhibitor of SARS-CoV-2 infection is crucial. A previous clinical DDI study of ensitrelvir with midazolam, a clinical index...
17.
Efficacy of Integrated Online Mindfulness and Self-compassion Training for Adults With Atopic Dermatitis: A Randomized Clinical Trial
Kishimoto S, Watanabe N, Yamamoto Y, Imai T, Aida R, Germer C, et al.
JAMA Dermatol . 2023 May; 159(6):628-636. PMID: 37163257
Importance: Quality of life (QOL) of patients with atopic dermatitis (AD) is reported to be the lowest among skin diseases. To our knowledge, mindfulness and self-compassion training has not been...
18.
Spatial-spectral mapping to prepare frequency entangled qudits
Yang Z, Zeng Z, Tian Y, Wang S, Shimizu R, Wu H, et al.
Opt Lett . 2023 May; 48(9):2361-2364. PMID: 37126274
Entangled qudits, the high-dimensional entangled states, play an important role in the study of quantum information. How to prepare entangled qudits in an efficient and easy-to-operate manner is still a...
19.
Evaluation of Drug-Drug Interactions of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor, With Transporter Substrates Based on In Vitro and Clinical Studies
Shimizu R, Matsuzaki T, Oka R, Sonoyama T, Fukuhara T, Kuwata A, et al.
J Clin Pharmacol . 2023 Apr; 63(8):918-927. PMID: 37043676
Drug-drug interaction potentials of ensitrelvir, a novel oral inhibitor of 3C-like protease of severe acute respiratory syndrome coronavirus 2, for drug transporters were evaluated by in vitro and clinical studies....
20.
Electrochemical Epoxidation Catalyzed by Manganese Salen Complex and Carbonate with Boron-Doped Diamond Electrode
Roy P, Amanai K, Shimizu R, Kodera M, Kurahashi T, Kitayama K, et al.
Molecules . 2023 Feb; 28(4). PMID: 36838783
Epoxides are essential precursors for epoxy resins and other chemical products. In this study, we investigated whether electrochemically oxidizing carbonate ions could produce percarbonate to promote an epoxidation reaction in...