Ryan R Murray
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Explore the profile of Ryan R Murray including associated specialties, affiliations and a list of published articles.
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15
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3560
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Recent Articles
1.
Lacoste J, Haghighi M, Haider S, Reno C, Lin Z, Segal D, et al.
Cell
. 2024 Oct;
187(23):6725-6741.e13.
PMID: 39353438
Widespread sequencing has yielded thousands of missense variants predicted or confirmed as disease causing. This creates a new bottleneck: determining the functional impact of each variant-typically a painstaking, customized process...
2.
Zhong Q, Pevzner S, Hao T, Wang Y, Mosca R, Menche J, et al.
Mol Syst Biol
. 2016 Apr;
12(4):865.
PMID: 27107014
In cellular systems, biophysical interactions between macromolecules underlie a complex web of functional interactions. How biophysical and functional networks are coordinated, whether all biophysical interactions correspond to functional interactions, and...
3.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman G, Hao T, Richardson A, et al.
Cell
. 2016 Feb;
164(4):805-17.
PMID: 26871637
While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown....
4.
Rolland T, Tasan M, Charloteaux B, Pevzner S, Zhong Q, Sahni N, et al.
Cell
. 2014 Nov;
159(5):1212-1226.
PMID: 25416956
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality...
5.
Djebali S, Lagarde J, Kapranov P, Lacroix V, Borel C, Mudge J, et al.
PLoS One
. 2012 Jan;
7(1):e28213.
PMID: 22238572
The classic organization of a gene structure has followed the Jacob and Monod bacterial gene model proposed more than 50 years ago. Since then, empirical determinations of the complexity of...
6.
Yang X, Boehm J, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, et al.
Nat Methods
. 2011 Jun;
8(8):659-61.
PMID: 21706014
Functional characterization of the human genome requires tools for systematically modulating gene expression in both loss-of-function and gain-of-function experiments. We describe the production of a sequence-confirmed, clonal collection of over...
7.
Johannessen C, Boehm J, Kim S, Thomas S, Wardwell L, Johnson L, et al.
Nature
. 2010 Nov;
468(7326):968-72.
PMID: 21107320
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on...
8.
Salehi-Ashtiani K, Lin C, Hao T, Shen Y, Szeto D, Yang X, et al.
Genome Res
. 2009 Oct;
19(12):2334-42.
PMID: 19801531
Although a highly accurate sequence of the Caenorhabditis elegans genome has been available for 10 years, the exact transcript structures of many of its protein-coding genes remain unsettled. Approximately two-thirds...
9.
Temple G, Gerhard D, Rasooly R, Feingold E, Good P, Robinson C, et al.
Genome Res
. 2009 Sep;
19(12):2324-33.
PMID: 19767417
Since its start, the Mammalian Gene Collection (MGC) has sought to provide at least one full-protein-coding sequence cDNA clone for every human and mouse gene with a RefSeq transcript, and...
10.
Manichaikul A, Ghamsari L, Hom E, Lin C, Murray R, Chang R, et al.
Nat Methods
. 2009 Jul;
6(8):589-92.
PMID: 19597503
With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we...