Ryan M Cinalli
Overview
Explore the profile of Ryan M Cinalli including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
2378
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Recent Articles
1.
Pae J, Cinalli R, Marzio A, Pagano M, Lehmann R
Dev Cell
. 2017 Jul;
42(2):130-142.e7.
PMID: 28743001
The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by...
2.
Molotkov A, Mazot P, Brewer J, Cinalli R, Soriano P
Dev Cell
. 2017 May;
41(5):511-526.e4.
PMID: 28552557
Activation of the FGF signaling pathway during preimplantation development of the mouse embryo is known to be essential for differentiation of the inner cell mass and the formation of the...
3.
Cinalli R, Lehmann R
Nat Cell Biol
. 2013 Jun;
15(7):839-45.
PMID: 23728423
The primordial germ cells (PGCs) are the first cells to form during Drosophila melanogaster embryogenesis. Whereas the process of somatic cell formation has been studied in detail, the mechanics of...
4.
Anderson D, Gill J, Cinalli R, Nance J
Science
. 2008 Jun;
320(5884):1771-4.
PMID: 18583611
Early embryos of some metazoans polarize radially to facilitate critical patterning events such as gastrulation and asymmetric cell division; however, little is known about how radial polarity is established. Early...
5.
Cinalli R, Rangan P, Lehmann R
Cell
. 2008 Feb;
132(4):559-62.
PMID: 18295574
Germ cells are the only cell type capable of generating an entirely new organism. In order to execute germline-specific functions and to retain the capacity for totipotency, germ cells repress...
6.
Giraldez A, Cinalli R, Glasner M, Enright A, Thomson J, Baskerville S, et al.
Science
. 2005 Mar;
308(5723):833-8.
PMID: 15774722
MicroRNAs (miRNAs) are small RNAs that regulate gene expression posttranscriptionally. To block all miRNA formation in zebrafish, we generated maternal-zygotic dicer (MZdicer) mutants that disrupt the Dicer ribonuclease III and...
7.
Cinalli R, Herman C, Lew B, Wieman H, Thompson C, Rathmell J
Eur J Immunol
. 2005 Feb;
35(3):786-95.
PMID: 15719365
Signals that regulate T cell homeostasis are not fully understood. G protein-coupled receptors (GPCR), such as the chemokine receptors, may affect homeostasis by direct signaling or by guiding T cell...
8.
Hammerman P, Fox C, Cinalli R, Xu A, Wagner J, Lindsten T, et al.
Cancer Res
. 2004 Nov;
64(22):8341-8.
PMID: 15548703
Pim-2 is a transcriptionally regulated oncogenic kinase that promotes cell survival in response to a wide variety of proliferative signals. Deregulation of Pim-2 expression has been documented in several human...
9.
Kong M, Fox C, Mu J, Solt L, Xu A, Cinalli R, et al.
Science
. 2004 Oct;
306(5696):695-8.
PMID: 15499020
Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here we show that alpha4, a noncatalytic subunit...
10.
Elstrom R, Bauer D, Buzzai M, Karnauskas R, Harris M, Plas D, et al.
Cancer Res
. 2004 Jun;
64(11):3892-9.
PMID: 15172999
Cancer cells frequently display high rates of aerobic glycolysis in comparison to their nontransformed counterparts, although the molecular basis of this phenomenon remains poorly understood. Constitutive activity of the serine/threonine...