Ryan L Setten
Overview
Explore the profile of Ryan L Setten including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
606
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0
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Recent Articles
1.
Jadhav S, Setten R, Medina C, Cui X, Dowdy S
AAPS J
. 2023 Dec;
26(1):10.
PMID: 38133698
RNA therapeutics, including siRNAs, ASOs, and PMOs, have great potential to treat human disease. However, RNA therapeutics are too large, too charged, and/or too hydrophilic to cross the cellular membrane...
2.
Setten R, Dowdy S
Mol Ther Nucleic Acids
. 2022 Jul;
29:133-134.
PMID: 35847172
No abstract available.
3.
Dowdy S, Setten R, Cui X, Jadhav S
Nucleic Acid Ther
. 2022 May;
32(5):361-368.
PMID: 35612432
RNA therapeutics, including siRNAs, antisense oligonucleotides, and other oligonucleotides, have great potential to selectively treat a multitude of human diseases, from cancer to COVID to Parkinson's disease. RNA therapeutic activity...
4.
Setten R, Chomchan P, Epps E, Burnett J, Rossi J
RNA
. 2021 May;
PMID: 34039742
Enhancer RNAs (eRNA) are non-coding transcripts produced from active enhancers and have potential gene regulatory function. CCAAT enhancer-binding protein alpha (CEBPA) is a transcription factor generally involved in metabolism, cell...
5.
Setten R, Rossi J, Han S
Nat Rev Drug Discov
. 2019 Apr;
19(4):290.
PMID: 31019276
Errors in the alignment and structure of the siRNN and in the structure of the sisiRNA in the original version of Fig. 3 have been corrected.
6.
Setten R, Rossi J, Han S
Nat Rev Drug Discov
. 2019 Mar;
19(4):291.
PMID: 30886427
The use of the names for patisiran has been made consistent throughout the article in line with the journal style and typographical errors have been corrected.
7.
Setten R, Rossi J, Han S
Nat Rev Drug Discov
. 2019 Mar;
18(6):421-446.
PMID: 30846871
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of specific genes, but their therapeutic...
8.
Setten R, Lightfoot H, Habib N, Rossi J
Curr Pharm Biotechnol
. 2018 Jun;
19(8):611-621.
PMID: 29886828
Background: Oligonucleotide drug development has revolutionised the drug discovery field. Within this field, 'small' or 'short' activating RNAs (saRNA) are a more recently discovered category of short double-stranded RNA with...
9.
Sridevi P, Nhiayi M, Setten R, Wang J
PLoS One
. 2013 Oct;
8(10):e77495.
PMID: 24147007
TNF-Related Apoptosis Inducing Ligand (TRAIL) binds to and activates death receptors to stimulate caspase-8 and apoptosis with higher efficiency in cancer than normal cells but the development of apoptosis resistance...