Ryan L Parr
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Explore the profile of Ryan L Parr including associated specialties, affiliations and a list of published articles.
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13
Citations
308
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Recent Articles
1.
Parr R, Mills J, Harbottle A, Creed J, Crewdson G, Reguly B, et al.
Discov Med
. 2013 May;
15(83):213-20.
PMID: 23636138
Mitochondria and their associated genome are emerging as sophisticated indicators of prostate cancer biology. Alterations in the mitochondrial genome (mtgenome) have been implicated in cell proliferation, metastatic behavior, androgen independence,...
2.
Parr R, Jakupciak J, Birch-Machin M, Dakubo G
Expert Opin Med Diagn
. 2013 Mar;
1(2):169-82.
PMID: 23489304
Mutations in the mitochondrial genome have been reported as biomarkers for the detection of cancer. Hallmarks of cancer development include the accumulation of genetic alterations in the mitochondrial and nuclear...
3.
Parr R, Martin L
Hum Genomics
. 2012 Dec;
6:3.
PMID: 23244780
Developing early detection biosensors for disease has been the long‒held goal of the Human Genome Project, but with little success. Conversely, the biological properties of the mitochondrion coupled with the...
4.
Reguly B, Jakupciak J, Parr R
Can Urol Assoc J
. 2010 Oct;
4(5):E118-22.
PMID: 20944788
Recently, we described a 3.4-kb mitochondrial genome deletion having significance for identifying malignant and benign prostate tissues (p < 0.001). This biomarker was also present in normal appearing tissue, in...
5.
Just R, Loreille O, Molto J, Merriwether D, Woodward S, Matheson C, et al.
Forensic Sci Int Genet
. 2010 May;
5(3):231-5.
PMID: 20457081
This report describes a re-examination of the remains of a young male child recovered in the Northwest Atlantic following the loss of the Royal Mail Ship Titanic in 1912 and...
6.
Loreille O, Parr R, McGregor K, Fitzpatrick C, Lyon C, Yang D, et al.
J Forensic Sci
. 2010 Apr;
55(3):813-8.
PMID: 20384910
This report describes the identification of a merchant mariner who perished in 1948 when Northwest Airlines Flight 4422, a DC-4 carrying 24 seamen and six crew members crashed into Mount...
7.
Jakupciak J, Maggrah A, Maragh S, Maki J, Reguly B, Maki K, et al.
BMC Cancer
. 2008 Apr;
8:95.
PMID: 18402686
Background: Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from symptomatic women could potentially serve as a minimally invasive...
8.
Maki J, Robinson K, Reguly B, Alexander J, Wittock R, Aguirre A, et al.
Am J Clin Pathol
. 2007 Dec;
129(1):57-66.
PMID: 18089489
We report the usefulness of a 3.4-kb mitochondrial genome deletion (3.4 mtdelta) for molecular definition of benign, malignant, and proximal to malignant (PTM) prostate needle biopsy specimens. The 3.4 mtdelta...
9.
Dakubo G, Jakupciak J, Birch-Machin M, Parr R
Cancer Cell Int
. 2007 Mar;
7:2.
PMID: 17362521
Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to...
10.
Jakupciak J, Dakubo G, Maragh S, Parr R
Curr Opin Mol Ther
. 2007 Jan;
8(6):500-6.
PMID: 17243485
Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer,...