Ryan Dykstra
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Explore the profile of Ryan Dykstra including associated specialties, affiliations and a list of published articles.
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8
Citations
94
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Recent Articles
1.
Dykstra R, Sindhikara D
J Chem Inf Model
. 2025 Jan;
65(3):1585-1604.
PMID: 39880805
Potency optimization of macrocyclic peptides can include both modifying intermolecular interactions and modifying the conformational stability of the bioactive conformation. However, the number of possible modifications is vast. To identify...
2.
Yang Y, Tsien J, Dykstra R, Chen S, Wang J, Merchant R, et al.
Nat Chem
. 2023 Oct;
16(2):285-293.
PMID: 37884667
Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure-activity relationship (SAR) studies of aromatic scaffolds during drug discovery. Recently, the bicyclo[1.1.1]pentane (BCP) motif has...
3.
Zhou M, Tsien J, Dykstra R, Hughes J, Peters B, Merchant R, et al.
Nat Chem
. 2023 Mar;
15(4):550-559.
PMID: 36864142
In recent years, a variety of cycloalkyl groups with quaternary carbons, in particular cyclopropyl and cyclobutyl trifluoromethyl groups, have emerged as promising bioisosteres in drug-like molecules. The modular installation of...
4.
Altundas B, Alwedi E, Song Z, Gogoi A, Dykstra R, Gutierrez O, et al.
Nat Commun
. 2022 Oct;
13(1):6444.
PMID: 36307409
A dearomatization-dislocation-coupling cascade rapidly transforms aromatic isocyanides into highly functionalized cyclohexadienes. The facile cascade installs an exceptional degree of molecular complexity: three carbon-carbon bonds, two quaternary stereocenters, and three orthogonal...
5.
Lipp A, Badir S, Dykstra R, Gutierrez O, Molander G
Adv Synth Catal
. 2022 Mar;
363(14):3507-3520.
PMID: 35273472
A catalyst- and additive-free decarbonylative trifluoromethylthiolation of aldehyde feedstocks has been developed. This operationally simple, scalable, and open-to-air transformation is driven by the selective photoexcitation of electron donor-acceptor (EDA) complexes,...
6.
Luo Y, Gutierrez-Bonet A, Matsui J, Rotella M, Dykstra R, Gutierrez O, et al.
ACS Catal
. 2021 May;
9(9):8835-8842.
PMID: 34055458
Herein, the introduction of oxa- and azabenzonorbornadienes into photoredox/nickel dual catalysis in a regioselective and diastereoselective transformation is disclosed. The inherent advantages of this dual catalytic system allow the use...
7.
Xu B, Troian-Gautier L, Dykstra R, Martin R, Gutierrez O, Tambar U
J Am Chem Soc
. 2020 Mar;
142(13):6206-6215.
PMID: 32129997
Endergonic isomerizations are thermodynamically unfavored processes that are difficult to realize under thermal conditions. We report a photocatalytic and diastereoselective isomerization of acyclic cinnamyl chlorides to strained cyclopropanes. Quantum mechanical...
8.
Phelan J, Lang S, Compton J, Kelly C, Dykstra R, Gutierrez O, et al.
J Am Chem Soc
. 2018 Jun;
140(25):8037-8047.
PMID: 29916711
A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an...
9.
Cabrera-Afonso M, Lu Z, Kelly C, Lang S, Dykstra R, Gutierrez O, et al.
Chem Sci
. 2018 May;
9(12):3186-3191.
PMID: 29732101
This report details the development and implementation of a strategy to construct aryl- and heteroaryl sulfones Ni/photoredox dual catalysis. Using aryl sulfinate salts, the C-S bond can be forged at...