Ruth E Watkinson
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Explore the profile of Ruth E Watkinson including associated specialties, affiliations and a list of published articles.
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14
Citations
595
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Recent Articles
1.
Hung C, Haas G, Watkinson R, Chiu H, Kowdle S, Stevens C, et al.
bioRxiv
. 2024 Sep;
PMID: 39282406
Viruses have evolved myriad strategies to exploit the translation machinery of host cells to potentiate their replication. However, how paramyxovirus (PMVs) modulate cellular translation for their own benefit has not...
2.
Mason T, Whitston M, Hodgson J, Watkinson R, Lau Y, Abdulrazeg O, et al.
BMC Med
. 2021 Oct;
19(1):275.
PMID: 34663326
Background: The BNT162b2 mRNA vaccine has been shown to be effective at preventing serious COVID-19 events in clinical trials. There is less evidence on effectiveness in real-world settings, especially for...
3.
Rao S, Yao Y, Soares de Brito J, Yao Q, Shen A, Watkinson R, et al.
Cell Stem Cell
. 2021 Jan;
28(5):833-845.e5.
PMID: 33513358
Severe congenital neutropenia (SCN) is a life-threatening disorder most often caused by dominant mutations of ELANE that interfere with neutrophil maturation. We conducted a pooled CRISPR screen in human hematopoietic...
4.
Cox R, Sourimant J, Toots M, Yoon J, Ikegame S, Govindarajan M, et al.
Nat Microbiol
. 2020 Jul;
5(10):1232-1246.
PMID: 32661315
Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute...
5.
Thibault P, Watkinson R, Moreira-Soto A, Drexler J, Lee B
Adv Virus Res
. 2017 Apr;
98:1-55.
PMID: 28433050
The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human and domestic animal populations are defined by a broad collection of ecological and molecular factors that interact...
6.
Bottermann M, Lode H, Watkinson R, Foss S, Sandlie I, Andersen J, et al.
Sci Rep
. 2017 Apr;
7:45418.
PMID: 28382939
No abstract available.
7.
Bottermann M, Lode H, Watkinson R, Foss S, Sandlie I, Andersen J, et al.
Sci Rep
. 2016 Nov;
6:37457.
PMID: 27881870
During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching the cytosol...
8.
Watkinson R, Lee B
FEBS Lett
. 2016 Jun;
590(15):2494-511.
PMID: 27350027
Nipah virus (NiV, Henipavirus) is a highly lethal emergent zoonotic paramyxovirus responsible for repeated human outbreaks of encephalitis in South East Asia. There are no approved vaccines or treatments, thus...
9.
Foss S, Watkinson R, Grevys A, McAdam M, Bern M, Hoydahl L, et al.
J Immunol
. 2016 Mar;
196(8):3452-3459.
PMID: 26962230
Ab-coated viruses can be detected in the cytosol by the FcR tripartite motif-containing 21 (TRIM21), which rapidly recruits the proteasomal machinery and triggers induction of immune signaling. As such, TRIM21...
10.
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus
Watkinson R, McEwan W, Tam J, Vaysburd M, James L
PLoS Pathog
. 2015 Oct;
11(10):e1005253.
PMID: 26506431
Encapsidation is a strategy almost universally employed by viruses to protect their genomes from degradation and from innate immune sensors. We show that TRIM21, which targets antibody-opsonized virions for proteasomal...