Rupert G Fray
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Explore the profile of Rupert G Fray including associated specialties, affiliations and a list of published articles.
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28
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1573
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Recent Articles
1.
Pallucchini M, Franchini M, El-Ballat E, Narraidoo N, Pointer-Gleadhill B, Palframan M, et al.
Front Plant Sci
. 2024 Dec;
15:1469676.
PMID: 39649809
is a nitrogen fixing bacterium able to colonise a wide range of host plants and is marketed as a biofertiliser due to its ability to promote plant growth. This study...
2.
Woodcock C, Alsaleem M, Toss M, Lothion-Roy J, Harris A, Jeyapalan J, et al.
Discov Oncol
. 2024 Aug;
15(1):343.
PMID: 39127986
Background: N6-methyladenosine (mA) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a mA demethylase. Given...
3.
Baron F, Zhang M, Archer N, Bellows E, Knight H, Welham S, et al.
RNA
. 2023 Feb;
29(6):777-789.
PMID: 36810234
-methyladenosine (mA) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using mA-specific methylated...
4.
Lothion-Roy J, Haigh D, Harris A, Metzler V, Alsaleem M, Toss M, et al.
Front Genet
. 2023 Feb;
13:1096071.
PMID: 36733939
N-methyladenosine (mA) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the mA modification. These proteins, and the mA...
5.
Haigh D, Woodcock C, Lothion-Roy J, Harris A, Metzler V, Persson J, et al.
Cancers (Basel)
. 2022 Oct;
14(20).
PMID: 36291932
Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa...
6.
Harris A, Metzler V, Lothion-Roy J, Varun D, Woodcock C, Haigh D, et al.
Front Endocrinol (Lausanne)
. 2022 Oct;
13:1006101.
PMID: 36263323
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bicalutamide,...
7.
Zhang M, Bodi Z, Mackinnon K, Zhong S, Archer N, Mongan N, et al.
Nat Commun
. 2022 Mar;
13(1):1127.
PMID: 35236848
The methyltransferase complex (mA writer), which catalyzes the deposition of N-methyladenosine (mA) in mRNAs, is highly conserved across most eukaryotic organisms, but its components and interactions between them are still...
8.
Bhat S, Bielewicz D, Gulanicz T, Bodi Z, Yu X, Anderson S, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21785-21795.
PMID: 32817553
In , the METTL3 homolog, mRNA adenosine methylase (MTA) introduces -methyladenosine (mA) into various coding and noncoding RNAs of the plant transcriptome. Here, we show that an MTA-deficient mutant ()...
9.
Anderson S, Kramer M, Gosai S, Yu X, Vandivier L, Nelson A, et al.
Cell Rep
. 2018 Nov;
25(5):1146-1157.e3.
PMID: 30380407
N-methyladenosine (mA) is a dynamic, reversible, covalently modified ribonucleotide that occurs predominantly toward 3' ends of eukaryotic mRNAs and is essential for their proper function and regulation. In Arabidopsis thaliana,...
10.
Ruzicka K, Zhang M, Campilho A, Bodi Z, Kashif M, Saleh M, et al.
New Phytol
. 2017 May;
215(1):157-172.
PMID: 28503769
N6-adenosine methylation (m A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined...