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Rui-Chun Lu

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Articles 10
Citations 167
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Recent Articles
1.
Lu R, Yang W, Tan L, Sun F, Tan M, Zhang W, et al.
Oncotarget . 2017 Dec; 8(54):93219-93226. PMID: 29190991
Genome-wide association studies (GWAS) have identified one single-nucleotide polymorphism (SNP) rs9271192 within as a risk factor for Alzheimer's disease (AD) in Caucasians. The effect of rs9271192 on AD needed to...
2.
Lu R, Tan M, Wang H, Xie A, Yu J, Tan L
Biomed Res Int . 2014 Nov; 2014:435203. PMID: 25431764
Alzheimer's disease (AD) is the most common neurodegenerative disease that caused dementia which has no effective treatment. Growing evidence has demonstrated that AD is a "protein misfolding disorder" that exhibits...
3.
Wang H, Tan M, Lu R, Yu J, Tan L
Biomed Res Int . 2014 Aug; 2014:239164. PMID: 25147790
Heat shock proteins 70 and heat shock proteins 90 (Hsp70/90) have been implicated in many crucial steps of carcinogenesis: stabilizing oncogenic proteins, inhibiting programmed cell death and replicative senescence, induction...
4.
Liu Y, Yu J, Zhang W, Zong Y, Lu R, Zhou J, et al.
J Neuroimmunol . 2014 Apr; 271(1-2):43-8. PMID: 24703098
Inhibition of interleukin-23 (IL-23) signaling was reported to reduce AD pathology, and IL-23 receptor gene (IL23R) which encodes IL-23 receptor may represent a candidate susceptibility gene for AD. Here, we...
5.
Lu R, Wang H, Tan M, Yu J, Tan L
J Neural Transm (Vienna) . 2013 Oct; 121(3):283-7. PMID: 24166182
Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated...
6.
Xia M, Yu J, Miao D, Lu R, Zheng X, Tan L
J Neurol Sci . 2013 Oct; 336(1-2):48-51. PMID: 24139700
Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found...
7.
Yu N, Yu J, Xiao J, Zhang H, Lu R, Jiang H, et al.
Neurosci Lett . 2011 Jan; 491(1):83-6. PMID: 21219968
Tau-tubuline kinase 1 (TTBK1) is a recently discovered brain-specific protein kinase involved in tau phosphorylation at AD-related sites. A recent large study has identified significant association of two single nucleotide...
8.
Wu Z, Zhang W, Yu J, Zhang Q, Tian Y, Lu R, et al.
Brain Res . 2010 Dec; 1374:129-33. PMID: 21167819
Apoptosis and autophagy are common physiological and pathological processes in the human body. Death-associated kinase protein 1 (DAPK1), which participates in the process of cell death, has attracted people's attention...
9.
Zhang N, Yu J, Yu N, Lu R, Ma T, Wang N, et al.
Brain Res Bull . 2010 Jan; 81(6):590-4. PMID: 20097272
Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have...
10.
Yu N, Wang X, Yu J, Wang N, Lu R, Miao D, et al.
Brain Res . 2010 Jan; 1317:305-10. PMID: 20059989
Environmental factors play an important role in the Alzheimer's disease (AD) development and stress may accelerate the progression of AD. Beta-adrenergic receptors are activated by stress and may influence different...