Ruben Rene Gonzalez-Perez
Overview
Explore the profile of Ruben Rene Gonzalez-Perez including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
266
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0
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Recent Articles
1.
Daley-Brown D, Harbuzariu A, Kurian A, Oprea-Ilies G, Gonzalez-Perez R
World J Clin Oncol
. 2019 Aug;
10(6):222-233.
PMID: 31367531
Background: Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and...
2.
Harbuzariu A, Gonzalez-Perez R
Oncotarget
. 2018 May;
9(26):18239-18253.
PMID: 29719602
5-FU chemotherapy is a current strategy to treat pancreatic cancer (PC), but unfortunately chemoresistance is eventually developed in most patients. Obesity is a risk factor for PC that could affect...
3.
Daley-Brown D, Oprea-Iles G, Vann K, Lanier V, Lee R, Candelaria P, et al.
Dis Markers
. 2017 Jun;
2017:8248175.
PMID: 28659656
Objective: The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa). Additionally, the involvement...
4.
Lanier V, Gillespie C, Leffers M, Daley-Brown D, Milner J, Lipsey C, et al.
Int J Biochem Cell Biol
. 2016 Sep;
79:139-150.
PMID: 27590851
Leptin increases vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), and Notch expression in cancer cells, and transphosphorylates VEGFR-2 in endothelial cells. However, the mechanisms involved in leptin's actions in...
5.
Mullen M, Gonzalez-Perez R
Vaccines (Basel)
. 2016 Jul;
4(3).
PMID: 27472371
Growth factor and cytokine signaling can influence the development of several cancer types. One of the key players in the development of cancer is the Janus kinas (JAK) signal transducer...
6.
Colbert L, Wilson K, Kim S, Liu Y, Oprea-Ilies G, Gillespie C, et al.
BMC Cancer
. 2014 Apr;
14:249.
PMID: 24716804
Background: Notch, IL-1 and leptin are known pro-angiogenic factors linked to breast cancer development, tumor aggressiveness and poor prognosis. A complex crosstalk between these molecules (NILCO) has been reported in...
7.
Gonzalez-Perez R, Lanier V, Newman G
Cancers (Basel)
. 2013 Nov;
5(3):1140-62.
PMID: 24202338
Obesity is linked to increased incidence of breast cancer. The precise causes and mechanisms of these morbid relationships are unknown. Contradictory data on leptin angiogenic actions have been published. However,...
8.
Newman G, Gonzalez-Perez R
Mol Cell Endocrinol
. 2013 Apr;
382(1):570-582.
PMID: 23562747
Despite accumulating evidence suggesting a positive correlation between leptin levels, obesity, post-menopause and breast cancer incidence, our current knowledge on the mechanisms involved in these relationships is still incomplete. Since...