Ruben L Gonzalez Jr
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Explore the profile of Ruben L Gonzalez Jr including associated specialties, affiliations and a list of published articles.
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61
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2135
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Recent Articles
1.
Gentry R, Ide N, Comunale V, Hartwick E, Kinz-Thompson C, Gonzalez Jr R
Nature
. 2024 Dec;
637(8046):736-743.
PMID: 39663447
During translation initiation, mRNA molecules must be identified and activated for loading into a ribosome. In this rate-limiting step, the heterotrimeric protein eukaryotic initiation factor eIF4F must recognize and productively...
2.
Jang S, Ray K, Lynall D, Shepard K, Nuckolls C, Gonzalez Jr R
bioRxiv
. 2024 Jun;
PMID: 38853856
Recent studies have demonstrated that the mechanisms through which biopolymers like RNA interconvert between multiple folded structures are critical for their cellular functions. A major obstacle to elucidating these mechanisms...
3.
Ide N, Gentry R, Rudbach M, Yoo K, Velez P, Comunale V, et al.
bioRxiv
. 2024 May;
PMID: 38712078
Eukaryotic translation initiation factor (eIF) 3 is a multi-subunit protein complex that binds both ribosomes and messenger RNAs (mRNAs) to drive a diverse set of mechanistic steps during translation of...
4.
Verma A, Ray K, Bodick M, Kinz-Thompson C, Gonzalez Jr R
Biophys J
. 2024 Jan;
123(17):2765-2780.
PMID: 38268189
Time-dependent single-molecule experiments contain rich kinetic information about the functional dynamics of biomolecules. A key step in extracting this information is the application of kinetic models, such as hidden Markov...
5.
Gentry R, Ide N, Comunale V, Hartwick E, Kinz-Thompson C, Gonzalez Jr R
bioRxiv
. 2023 Nov;
PMID: 38014128
During translation initiation, messenger RNA molecules must be identified and activated for loading into a ribosome. In this rate-limiting step, the heterotrimeric protein eukaryotic initiation factor eIF4F must recognize and...
6.
Ray K, Verma A, Gonzalez Jr R, Kinz-Thompson C
Proc Math Phys Eng Sci
. 2023 Sep;
478(2266):20220177.
PMID: 37767180
A critical step in data analysis for many different types of experiments is the identification of features with theoretically defined shapes in -dimensional datasets; examples of this process include finding...
7.
Verma A, Ray K, Bodick M, Kinz-Thompson C, Gonzalez Jr R
bioRxiv
. 2023 Aug;
PMID: 37645812
Time-dependent single-molecule experiments contain rich kinetic information about the functional dynamics of biomolecules. A key step in extracting this information is the application of kinetic models, such as hidden Markov...
8.
Hassan A, Byju S, Freitas F, Roc C, Pender N, Nguyen K, et al.
Nucleic Acids Res
. 2022 Dec;
51(2):919-934.
PMID: 36583339
Protein synthesis by the ribosome requires large-scale rearrangements of the 'small' subunit (SSU; ∼1 MDa), including inter- and intra-subunit rotational motions. However, with nearly 2000 structures of ribosomes and ribosomal...
9.
Jang S, Dubnik S, Hon J, Hellenkamp B, Lynall D, Shepard K, et al.
J Am Chem Soc
. 2022 Dec;
145(1):402-412.
PMID: 36547391
We have developed and used single-molecule field-effect transistors (smFETs) to characterize the conformational free-energy landscape of RNA stem-loops. Stem-loops are one of the most common RNA structural motifs and serve...
10.
Bailey E, Gottesman M, Gonzalez Jr R
J Mol Biol
. 2021 Oct;
434(2):167330.
PMID: 34710399
In bacteria, transcription is coupled to, and can be regulated by, translation. Although recent structural studies suggest that the N-utilization substance G (NusG) transcription factor can serve as a direct,...