Roy A Wise
Overview
Explore the profile of Roy A Wise including associated specialties, affiliations and a list of published articles.
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66
Citations
6368
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Recent Articles
1.
You Z, Galaj E, Alen F, Wang B, Bi G, Moore A, et al.
Neuropsychopharmacology
. 2021 Dec;
47(8):1449-1460.
PMID: 34923576
Cocaine addiction is a significant medical and public concern. Despite decades of research effort, development of pharmacotherapy for cocaine use disorder remains largely unsuccessful. This may be partially due to...
2.
Wise R, Jordan C
J Biomed Sci
. 2021 Dec;
28(1):83.
PMID: 34852810
Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they lack learned seeking...
3.
Marino R, McDevitt R, Gantz S, Shen H, Pignatelli M, Xin W, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(15):8611-8615.
PMID: 32229573
Electrical or optogenetic stimulation of lateral hypothalamic (LH) GABA neurons induces rapid vigorous eating in sated animals. The dopamine system has been implicated in the regulation of feeding. Previous work...
4.
Wise R, Robble M
Annu Rev Psychol
. 2020 Jan;
71:79-106.
PMID: 31905114
Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is usually defined by characteristics of intoxication or by characteristics of withdrawal symptoms. Such addictions can also be defined...
5.
You Z, Wang B, Gardner E, Wise R
Pharmacol Biochem Behav
. 2018 Nov;
176:53-56.
PMID: 30414405
The dopamine system-essential for mood and movement-can be activated in two ways: by excitatory inputs that cause burst firing and stamp-in learning or by slow excitatory or inhibitory inputs-like leptin,...
6.
Volkow N, Wise R, Baler R
Nat Rev Neurosci
. 2017 Nov;
18(12):741-752.
PMID: 29142296
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin with a motivation to initiate the behaviour. Both this motivational drive and the behaviours that follow are influenced...
7.
Wise R, McDevitt R
Neuropsychopharmacology
. 2017 Oct;
43(4):680-689.
PMID: 28984293
Brain stimulation has identified two central subsets of stimulation sites with motivational relevance. First, there is a large and disperse set of sites where stimulation is reinforcing, increasing the frequency...
8.
Gigante E, Benaliouad F, Zamora-Olivencia V, Wise R
PLoS One
. 2016 Jul;
11(7):e0158885.
PMID: 27387668
Electrical stimulation of the lateral hypothalamus can motivate feeding or can serve as a reward in its own right. It remains unclear whether the same or independent but anatomically overlapping...
9.
Barbano M, Wang H, Morales M, Wise R
J Neurosci
. 2016 Mar;
36(10):2975-85.
PMID: 26961951
Electrical stimulation of the lateral hypothalamus (LH) has two motivational effects: long trains of stimulation induce drive-like effects such as eating, and short trains are rewarding. It has not been...
10.
Stuber G, Wise R
Nat Neurosci
. 2016 Jan;
19(2):198-205.
PMID: 26814589
In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was identified as a critical neuroanatomical substrate for motivated behavior. Electrical stimulation of the LHA induces voracious feeding...