Roshan K Dhungana
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Explore the profile of Roshan K Dhungana including associated specialties, affiliations and a list of published articles.
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26
Citations
418
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Recent Articles
1.
Aryal V, Chesley L, Niroula D, Sapkota R, Dhungana R, Giri R
ACS Catal
. 2023 Oct;
12(12):7262-7268.
PMID: 37829145
We disclose a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ-alkenylketimines with aryl halides and alkylzinc reagents. The reaction produces γ-C(sp)-branched δ-arylketones with the construction of two new C(sp)-C(sp) and...
2.
Chesley L, Poudel D, Sapkota R, Dhungana R, Lakomy M, Giri R
ACS Omega
. 2023 Jun;
8(22):19912-19916.
PMID: 37305246
We disclose a palladium-catalyzed difunctionalization of skipped diene with alkenyl triflates and arylboronic acids to produce 1,3-alkenylarylated products. The reaction proceeded efficiently with Pd(acac) as a catalyst and CsF as...
3.
Majhi J, Granados A, Matsuo B, Ciccone V, Dhungana R, Sharique M, et al.
Chem Sci
. 2023 Feb;
14(4):897-902.
PMID: 36755706
The synthetic application of (hetero)aryl radicals in organic synthesis has been known since the last century. However, their applicability has significantly suffered from ineffective generation protocols. Herein, we present a...
4.
Wickham L, Dhungana R, Giri R
ACS Omega
. 2023 Jan;
8(1):1060-1066.
PMID: 36643521
Dicarbofunctionalization is an important efficient synthetic technique for adding two chemical moieties across an alkene. Here, a novel method of reductive dicarbofunctionalization has been developed using a single alkenyl triflate...
5.
Zheng Y, Huang W, Dhungana R, Granados A, Keess S, Makvandi M, et al.
J Am Chem Soc
. 2022 Dec;
144(51):23685-23690.
PMID: 36523116
The development of synthetic strategies for the preparation of bioisosteric compounds is a demanding undertaking in medicinal chemistry. Numerous strategies have been developed for the synthesis of bicyclo[1.1.1]pentanes (BCPs), bridge-substituted...
6.
Majhi J, Dhungana R, Renteria-Gomez A, Sharique M, Li L, Dong W, et al.
J Am Chem Soc
. 2022 Aug;
144(34):15871-15878.
PMID: 35984388
The concurrent installation of C-C and C-N bonds across alkene frameworks represents a powerful tool to prepare motifs that are ubiquitous in pharmaceuticals and bioactive compounds. To construct such prevalent...
7.
Sapkota R, Tak R, Aryal V, Niroula D, Secosky N, Dhungana R, et al.
Org Lett
. 2022 Aug;
24(33):6213-6218.
PMID: 35969494
We report a Cu(II)-catalyzed cyclization/coupling of alkenyl aldimines with arylzinc reagents to create indole-3-diarylmethane derivatives (Sapkota et al. , DOI: 10.26434/chemrxiv-2022-d6qn). The current reaction provides a unified modular route from...
8.
Dhungana R, Granados A, Sharique M, Majhi J, Molander G
Chem Commun (Camb)
. 2022 Aug;
58(68):9556-9559.
PMID: 35930003
Herein, we report a three-component organophotoredox coupling of -alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C-C and C-Y (Y = S/O/N) bonds in...
9.
Granados A, Dhungana R, Sharique M, Majhi J, Molander G
Org Lett
. 2022 Jun;
24(26):4750-4755.
PMID: 35766376
An operationally simple and practical method is disclosed to achieve the difunctionalization of styrenes, generating fluorinated benzyl bromides via a photoinduced atom transfer radical addition process. The developed method is...
10.
Sharique M, Majhi J, Dhungana R, Kammer L, Krumb M, Lipp A, et al.
Chem Sci
. 2022 Jun;
13(19):5701-5706.
PMID: 35694363
An operationally simple, open-air, and efficient light-mediated Minisci C-H alkylation method is described, based on the formation of an electron donor-acceptor (EDA) complex between nitrogen-containing heterocycles and redox-active esters. In...