Rosa A Luirink
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Explore the profile of Rosa A Luirink including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
31
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Recent Articles
1.
Paulussen F, Schouten G, Moertl C, Verheul J, Hoekstra I, Koningstein G, et al.
J Am Chem Soc
. 2022 Aug;
144(33):15303-15313.
PMID: 35945166
The use of antibiotics is threatened by the emergence and spread of multidrug-resistant strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In this...
2.
Luirink R, Verkade-Vreeker M, Commandeur J, Geerke D
Chembiochem
. 2020 Jan;
21(10):1461-1472.
PMID: 31919943
The regio- (and stereo-)selectivity and specific activity of cytochrome P450s are determined by the accessibility of potential sites of metabolism (SOMs) of the bound substrate relative to the heme, and...
3.
Van Der Steen N, Zwaenepoel K, Mazzaschi G, Luirink R, Geerke D, Op de Beeck K, et al.
Molecules
. 2019 Dec;
24(24).
PMID: 31817278
The c-Met receptor is a therapeutically actionable target in non-small-cell lung cancer (NSCLC), with one approved drug and several agents in development. Most suitable biomarkers for patient selection include c-Met...
4.
Luirink R, Dekker S, Capoferri L, Janssen L, Kuiper C, Ari M, et al.
J Inorg Biochem
. 2018 May;
184:115-122.
PMID: 29723739
The 5'-hydroxymethyl metabolite of the penicillin based antibiotic flucloxacillin (FLX) is considered to be involved in bile duct damage occurring in a small number of patients. Because 5'-hydroxymethyl FLX is...
5.
Ortega Ugalde S, Luirink R, Geerke D, Vermeulen N, Bitter W, Commandeur J
J Inorg Biochem
. 2017 Dec;
180:47-53.
PMID: 29232638
CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb) that have been structurally characterized. Despite several efforts for its functional characterization, CYP130 is still considered an orphan...
6.
Visscher K, Vosmeer C, Luirink R, Geerke D
J Comput Chem
. 2017 Jan;
38(8):508-517.
PMID: 28133840
In this work, parameters are optimized for a charge-on-spring based polarizable force field for linear alcohols. We show that parameter transferability can be obtained using a systematic approach in which...