Rory B Conolly
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Explore the profile of Rory B Conolly including associated specialties, affiliations and a list of published articles.
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58
Citations
730
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Recent Articles
1.
Conolly R, Schroeter J, Kimbell J, Clewell H, Andersen M, Gentry P
Toxicol Sci
. 2023 Mar;
193(1):1-17.
PMID: 36912747
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry....
2.
Liu R, Zacharewski T, Conolly R, Zhang Q
Toxics
. 2022 Nov;
10(11).
PMID: 36422908
Humans are exposed to persistent organic pollutants, such as dioxin-like compounds (DLCs), as mixtures. Understanding and predicting the toxicokinetics and thus internal burden of major constituents of a DLC mixture...
3.
Conolly R, Campbell J, Clewell H, Schroeter J, Kimbell J, Gentry P
Toxicol Sci
. 2022 Nov;
191(1):15-24.
PMID: 36409013
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the...
4.
Villeneuve D, Blackwell B, Blanksma C, Cavallin J, Cheng W, Conolly R, et al.
Environ Toxicol Chem
. 2022 Oct;
42(1):100-116.
PMID: 36282016
To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide...
5.
Zhang Q, Caudle W, Pi J, Bhattacharya S, Andersen M, Kaminski N, et al.
Curr Opin Toxicol
. 2019 Nov;
16:49-57.
PMID: 31768481
As systems biology expands its multi-omic spectrum to increasing resolutions, distinguishing cells based on single-cell profiles becomes feasible. Unlike traditional bulk assays that average cellular responses and blur the distinct...
6.
Hines D, Conolly R, Jarabek A
Environ Sci Technol
. 2019 Aug;
53(18):11002-11012.
PMID: 31436975
Exposure to environmental contaminants can lead to adverse outcomes in both human and nonhuman receptors. The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks can mechanistically inform cumulative...
7.
Hill T, Conolly R
Toxicol Sci
. 2019 Aug;
172(1):1-10.
PMID: 31407013
Traditional methods for carcinogenicity testing rely heavily on the rodent bioassay as the standard for identification of tumorigenic risk. As such, identification of species-specific outcomes and/or metabolism are a frequent...
8.
Kyle Martin W, Tennant A, Conolly R, Prince K, Stevens J, DeMarini D, et al.
Sci Rep
. 2019 Jan;
9(1):145.
PMID: 30644404
Heart rate assays in wild-type zebrafish embryos have been limited to analysis of one embryo per video/imaging field. Here we present for the first time a platform for high-throughput derivation...
9.
Zhang Q, Li J, Middleton A, Bhattacharya S, Conolly R
Front Public Health
. 2018 Sep;
6:261.
PMID: 30255008
Chemical toxicity testing is moving steadily toward a human cell and organoid-based approach for reasons including scientific relevancy, efficiency, cost, and ethical rightfulness. Inferring human health risk from chemical exposure...
10.
Cheng W, Duncan K, Ghio A, Ward-Caviness C, Karoly E, Diaz-Sanchez D, et al.
Toxicol Sci
. 2018 Feb;
163(2):430-439.
PMID: 29471466
Controlled human exposure to the oxidant air pollutant ozone causes decrements in lung function and increased inflammation as evidenced by neutrophil influx into the lung and increased levels of proinflammatory...