Romeo Cecchelli
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Explore the profile of Romeo Cecchelli including associated specialties, affiliations and a list of published articles.
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2820
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Recent Articles
1.
Praca C, Rosa S, Sevin E, Cecchelli R, Dehouck M, Ferreira L
Stem Cell Reports
. 2019 Sep;
13(4):599-611.
PMID: 31495714
The derivation of human brain capillary endothelial cells is of utmost importance for drug discovery programs focusing on diseases of the central nervous system. Here, we describe a two-step differentiation...
2.
Praca C, Rai A, Santos T, Cristovao A, Pinho S, Cecchelli R, et al.
J Control Release
. 2018 Jun;
284:57-72.
PMID: 29902485
Stimulation of adult neurogenesis by targeting the endogenous neural stem cells (NSCs), located in hippocampus and subventricular zone (SVZ), with nanoformulations has been proposed for brain repair in cases of...
3.
Drolez A, Vandenhaute E, Delannoy C, Dewald J, Gosselet F, Cecchelli R, et al.
Int J Mol Sci
. 2016 Aug;
17(8).
PMID: 27529215
The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain....
4.
Jahne E, Eigenmann D, Sampath C, Butterweck V, Culot M, Cecchelli R, et al.
Planta Med
. 2016 Apr;
82(11-12):1021-9.
PMID: 27093249
The indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with a unique pharmacological profile. It is a potent inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed leukotriene synthesis, and nitric oxide...
5.
In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
Eigenmann D, Durig C, Jahne E, Smiesko M, Culot M, Gosselet F, et al.
Eur J Pharm Biopharm
. 2016 Mar;
103:118-126.
PMID: 27018328
The alkaloid piperine from black pepper (Piper nigrum L.) and several synthetic piperine analogs were recently identified as positive allosteric modulators of γ-aminobutyric acid type A (GABAA) receptors. In order...
6.
Drolez A, Vandenhaute E, Julien S, Gosselet F, Burchell J, Cecchelli R, et al.
PLoS One
. 2016 Mar;
11(3):e0151155.
PMID: 26958843
Around 7-17% of metastatic breast cancer patients will develop brain metastases, associated with a poor prognosis. To reach the brain parenchyma, cancer cells need to cross the highly restrictive endothelium...
7.
Helms H, Abbott N, Burek M, Cecchelli R, Couraud P, Deli M, et al.
J Cereb Blood Flow Metab
. 2016 Feb;
36(5):862-90.
PMID: 26868179
The endothelial cells lining the brain capillaries separate the blood from the brain parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial interface for exchange of...
8.
Oller-Salvia B, Sanchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, et al.
Angew Chem Int Ed Engl
. 2015 Oct;
55(2):572-5.
PMID: 26492861
Drug delivery across the blood-brain barrier (BBB) is a formidable challenge for therapies targeting the central nervous system. Although BBB shuttle peptides enhance transport into the brain non-invasively, their application...
9.
Schultz L, Zurich M, Culot M, da Costa A, Landry C, Bellwon P, et al.
Toxicol In Vitro
. 2015 Jun;
30(1 Pt A):138-65.
PMID: 26026931
The present study was performed in an attempt to develop an in vitro integrated testing strategy (ITS) to evaluate drug-induced neurotoxicity. A number of endpoints were analyzed using two complementary...
10.
Karamanos Y, Gosselet F, Dehouck M, Cecchelli R
Arch Med Res
. 2014 Dec;
45(8):730-7.
PMID: 25446619
The blood-brain barrier (BBB) regulates the passage of endogenous and exogenous compounds and thus contributes to the brain homeostasis with the help of well-known proteins such as tight junction proteins,...