Roman Jirak
Overview
Explore the profile of Roman Jirak including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
335
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0
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Recent Articles
1.
Fisar Z, Hroudova J, Zverova M, Jirak R, Raboch J, Kitzlerova E
Biomedicines
. 2023 Jun;
11(6).
PMID: 37371659
Mitochondrial dysfunction is an important cellular hallmark of aging and neurodegeneration. Platelets are a useful model to study the systemic manifestations of mitochondrial dysfunction. To evaluate the age dependence of...
2.
Fisar Z, Hansikova H, Krizova J, Jirak R, Kitzlerova E, Zverova M, et al.
Mitochondrion
. 2019 Aug;
48:67-77.
PMID: 31377247
We analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression....
3.
Habartova L, Hrubesova K, Syslova K, Vondrousova J, Fisar Z, Jirak R, et al.
Clin Biochem
. 2019 Apr;
72:58-63.
PMID: 30954438
Objectives: With over 35 million cases worldwide, Alzheimer's disease (AD) represents the main cause of dementia. The differentiation of AD from other types of dementia is challenging and its early...
4.
Fisar Z, Jirak R, Zverova M, Setnicka V, Habartova L, Hroudova J, et al.
Clin Biochem
. 2019 Apr;
72:71-80.
PMID: 30954436
Objectives: Altered amyloid metabolism and mitochondrial dysfunction play key roles in the development of Alzheimer's disease (AD). We asked whether an association exists between disturbed platelet mitochondrial respiration and the...
5.
Hrubesova K, Fouskova M, Habartova L, Fisar Z, Jirak R, Raboch J, et al.
Clin Biochem
. 2019 Apr;
72:39-51.
PMID: 30953619
Due to the trend of prolonged lifespan leading to higher incidence of age-related diseases, the demand for reliable biomarkers of dementia rises. In this review, we present novel biomarkers of...
6.
Zverova M, Kitzlerova E, Fisar Z, Jirak R, Hroudova J, Benakova H, et al.
Curr Alzheimer Res
. 2018 Jun;
15(10):938-950.
PMID: 29852871
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis and a common occurrence of comorbid diseases such as depression. It is accepted that the presence of...
7.
Kitzlerova E, Fisar Z, Lelkova P, Jirak R, Zverova M, Hroudova J, et al.
Med Sci Monit
. 2018 Apr;
24:2599-2619.
PMID: 29703883
BACKGROUND Several genetic susceptibility loci for major depressive disorder (MDD) or Alzheimer's disease (AD) have been described. Interactions among polymorphisms are thought to explain the differences between low- and high-risk...
8.
Fisar Z, Hroudova J, Hansikova H, Spacilova J, Lelkova P, Wenchich L, et al.
Curr Alzheimer Res
. 2016 Mar;
13(8):930-41.
PMID: 26971932
Mitochondrial dysfunctions significantly contribute to the pathogenesis of Alzheimer's disease (AD). Here, we studied the relationship between AD and changes in the mitochondrial rates of respiration in blood platelets, respiratory...
9.
Kitzlerova E, Fisar Z, Jirak R, Zverova M, Hroudova J, Benakova H, et al.
Neuro Endocrinol Lett
. 2014 Mar;
35(1):42-9.
PMID: 24625917
Objective: Elevated homocysteine is associated with a variety of diseases, including Alzheimer's disease (AD) and depressive disorder. This study was designed to detect an association between plasma homocysteine and AD...
10.
Platenik J, Fisar Z, Buchal R, Jirak R, Kitzlerova E, Zverova M, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2013 Dec;
50:83-93.
PMID: 24334212
Background: Glycogen synthase kinase-3β (GSK3β), cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) play critical roles in neuronal survival, synaptic plasticity and memory and participate in the pathophysiology of...